31PRACTICE PROBLEM A dominant allele (H) is the cause of the genetic condition known as Huntington's disease. A person who inherits one copy of the H allele will develop the disease later in life, typically between ages 30 and 50. If a population is in Hardy-Weinberg equilibrium for the...
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In this report, we propose a likelihood ratio test for Hardy –Weinberg equilibrium that accommodates a mixture of pedigree and random sample data. The underlying statistical model depends on a parameter c determining the ratio of heterozygous genotypes to homozygous genotypes among pedigree founders....
Bayesian test procedures for Hardy–Weinberg equilibrium for the autosomes have been described, but Bayesian work on the X chromosome in this context is lacking. This paper gives the first Bayesian approach for testing Hardy–Weinberg equilibrium with biallelic markers at the X chromosome. Marginal ...