在谱系的背景下,共享单倍型仅通过共同祖先来获得。第二类方法,也是hap-ibd使用的方法,寻找在phased或没有phased基因型数据中相同等位基因的长片段。这方法没有将成对的单倍体分为“IBD”和“非IBD”,而是将其分为“长IBD”和“非长IBD”。理想情况下,检测的 IBD 片段应主要来自单个共同祖先的 IBD,而不是来自多...
Define HapMap. HapMap synonyms, HapMap pronunciation, HapMap translation, English dictionary definition of HapMap. n. A database of common genetic variants in human beings from various regions of the world, the result of an international project to descr
crosshapwas originally designed to explore local haplotype patterns that may underlie phenotypic variability in quantitative trait locus (QTL) regions. It is ideally suited to complement and follow-up GWAS results (takes same inputs).crosshapequips users with the tools to explain why a region repor...
A web-based tool for identification and annotation of proxy SNPs using HapMap. A Johnson,Handsaker,Re,... 被引量: 0发表: 2014年 LocusZoom: regional visualization of genome-wide association scan results Genome-wide association studies (GWAS) have revealed hundreds of loci associated with common ...
Availability: HAPGEN2 is freely available from http://www.stats.ox.ac.uk/~marchini/software/gwas/gwas.html. Contact: zhan@well.ox.ac.uk Supplementary information: Supplementary data are available at Bioinformatics online.Su ZhanMarchini Jonathan...
In total, we identified 25 cis–trans regulated genes that have been implicated in complex disorders using the web tool GWAS Catalog (http://genome.gov/26525384). For example (Table 2), we identified a two-locus interaction between a trans-SNP 5.9 kb upstream of CCL4 (MIM 182284) and a...
identifiedbasedonobservedLDpatternsinHapMap.Researchers areincreasinglyturningtometa-analysisacrossmultiple GWAS ∗ To whom correspondence should be addressed. † The authors wish it to be known that, in their opinion, the first two authors ...
The new method, HAPGEN2, retains many advantages of resampling methods and expands the range of disease models that current simulators offer.Availability: HAPGEN2 is freely available from http://www.stats.ox.ac.uk/~marchini/software/gwas/gwas.html.Contact: zhan@well.ox.ac.ukSupplementary ...