Oral mucositis (OM) in cancer patients induced by chemotherapy or radiotherapy has a significant impact on quality of life, and causes considerable morbidity. Oral microorganisms are likely to intensify the inflammatory process and aggravate the formation of ulcers. Hangeshashinto (HST), a Japanese ...
Background : The current pooled analysis evaluated the efficacy of Hangeshashinto (TJ-14) in the prevention and/or treatment of chemotherapy-induced oral mucositis (COM) in gastric cancer and colorectal cancer using two prospective, multi-institutional, randomized, double-blind, placebo-controlled ...
“HOKs were treated with various ingredients of scutellaria root (baicalin, baicalein and wogonin), processed ginger ([6]-shogaol, [8]-shogaol, [10]-shogaol, [6]-gingerol, [8]-gingerol and [10]-gingerol) and Glycyrrhiza (glycyrrhizin, Liquiritin, Isoliquiritin, Liquiritin apioside, and Iso...
HangeshashintoOral mucositisHematopoietic stem cell transplantationConditioning regimenCANCERIMPACTMANAGEMENTSEVERITYTJ-14BLOODPurpose: Oral mucositis (OM) is a side effect associated with cancer treatment. Hangeshashinto (HST), a Kampo medicine, was originally prescribed to treat diarrhea, gastritis, and ...
Purpose Radiation-induced oral mucositis is the most common side effect of radiotherapy in head and neck cancer; however, effective modalities for its prevention have not been established. In this study, we evaluated the effectiveness of Hangeshashinto (TJ-14), a Japanese herbal medicine, for ...
Introduction Hangeshashinto has been employed for oral mucositis prevention in patients receiving cancer treatment, but the evidence has not been sufficiently robust to guide clinical decision-making. This study will therefore be undertaken to assess the effectiveness of Hangeshashinto for preventing ...
Mouth-washing with the Japanese herbal medicine hangeshashinto (HST) ameliorates chemotherapy-induced OUM in patients with colorectal cancer. Previously, we demonstrated that HST decreased interleukin 1尾-induced prostaglandin E2 production in human oral keratinocytes (HOKs) and OUM-induced mechanical or...
Hangeshashinto (TJ-14) is a Kampo medicine that relieves chemotherapy-induced oral mucositis. We investigated the effect of TJ-14 on mucositis, nutritional status, and the completion rate of CRT.The study group comprised patients with advanced HNC who were treated with concomitant weekly cisplatin...
Yamashita T, Araki K, Tomifuji M, Kamide D and Tanaka Y: Traditional Japanese medicine-Hangeshashinto (TJ-14)- alleviates chemoradiation-induced mucositis and improves rates of treatment completion. Support Care Cancer 2015; 23(1): 29-35....
Nasal mucosaPhysiology functionObjective: Hangeshashinto is a Japanese Kampo medicine applied for the treatment of oral mucositis and gastroenteritis. Hangeshashinto exhibits broad-spectrum antibacterial activity and suppresses prostaglandin (PG)E2 production in the mucosa and has the ability to improve ...