researchers have sought to simplify the problem by providing a common framework to organize research efforts. The main output of this process was the definition of the 14 Hallmarks of Cancer, a common set of abnormalities that are common to ...
Douglas Hanahan,Robert A. Weinberg Madhusudana Girija Sanal A SIMPLER DEFINITION OF CANCER The following two conditions needs to be satisfied to define a cancer: 1)Non physiological rate and duration of cell proliferation.Non physiological rate is defined as a growth rate which is a statistical ...
need for heparanase-targeted therapies. However, recent discoveries which demonstrated that heparanase can also regulate vital anti-tumour mechanisms have cast doubt on this approach. This review will explore the myriad ways by which heparanase functions as a key regulator of the hallmarks of cancer a...
need for heparanase-targeted therapies. However, recent discoveries which demonstrated that heparanase can also regulate vital anti-tumour mechanisms have cast doubt on this approach. This review will explore the myriad ways by which heparanase functions as a key regulator of the hallmarks of cancer a...
Definition A zinc finger is a protein domain that can interact with DNA. Folding of the polypeptide chain, into finger-like projections that can intercalate with the DNA helix, is stabilized through interactions with a zinc atom. Many transcription factors and other regulatory proteins that ...
Cancer is caused by an accumulation of somatic mutations and copy number alterations (CNAs). Besides mutations, these copy number changes are key characteristics of cancer development. Nonetheless, some tumors show hardly any CNAs, a remarkable phenomeno
Myc Hallmarks of cancer stem cell metabolism Patricia Sancho*,1, David Barneda1 and Christopher Heeschen*,1 1Centre for Stem Cells in Cancer & Ageing, Barts Cancer Institute, Queen Mary University of London, London EC1M 6BQ, UK Cancer cells adapt cellular metabolism to cope with their high ...
of cancer research in previous decades. The cancer field gained major momentum in 2000, with the publication of a landmark paper that enumerated six hallmarks of cancer (Hanahan and Weinberg, 2000), recently expanded to ten (Hanahan and Weinberg, 2011). This categorization has helped to ...
Cancer cells adapt cellular metabolism to cope with their high proliferation rate. Instead of primarily using oxidative phosphorylation (OXPHOS), cancer cells use less efficient glycolysis for the production of ATP and building blocks (Warburg effect). H
A. Hallmarks of cancer: the next generation. Cell 144, 646–674 (2011). Article CAS PubMed Google Scholar Cui, Q. et al. A map of human cancer signaling. Mol Syst Biol 3, 152 (2007). Article PubMed PubMed Central CAS Google Scholar Dutkowski, J. & Ideker, T. Protein networks...