The latest developments of techniques that prolong the half-life of protein drugs were reviewed.The therapeutic potential of several proteins is limited by their rapid clearance from the body,resulting in the need for frequent treatment of individuals to maintain drug levels.Several techniques including...
these subcutaneous xenograft animal models. Neither negative (exhibits efficacy in human but not in mice) nor positive (exhibits efficacy in mice but not in human) predictive value of these models is clear. 多数现代被瞄准的疗法例如gleevec、herceptin和rituximab是更加可能无法这些皮肤下异种移植动物模型...
aMost modern targeted therapies such as gleevec, herceptin and rituximab are even more likely to fail in these subcutaneous xenograft animal models. Neither negative (exhibits efficacy in human but not in mice) nor positive (exhibits efficacy in mice but not in human) predictive value of these ...