When originally approved under the accelerated approval program, the long-term benefits of this second-line drug therapy in refractory CML could only be assumed. However, follow-up studies of the patients enrolled in the research studies have shown that 95 percent of those with refractory disease ...
Some side effects of dasatinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects...
Some side effects of nilotinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects...
For example, variability was noted in patients with chronic myeloid leukemia (CML), and the level of molecular response achieved with imatinib (Gleevec) therapy suggesting variability exists in the patient’s therapy adherence. A strong correlation between adherence rates of ≤ 90% or > 90% and ...
The term “antibody” as used herein refers to immunoglobulin molecules and immunologically active portions of immunoglobulin molecules, i.e., molecules that contain an antigen binding site that immunospecifically binds an antigen. As such, the term antibody encompasses not only whole antibody molecules...
to be active in certain types of leukemia, such as CML and AML. Both c- kit and FLT-3 are kinases that are active in CML. Gleevec targets c- kit, but not FLT-3, if I am not mistaken. It just may be that this young person you mention here has had molecular or gene testing and...
"The long-term success of this treatment confirms the remarkable success we've seen since the very first Gleevec trials," said Druker, director of the OHSU Knight Cancer Institute, a Howard Hughes Medical Institute Investigator and JELD-WEN Chair of Leukemia Research in the OHSU School of Medici...
Other side effects of Jakafi Some side effects of ruxolitinib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or ...