Microscopically, the hair shaft takes on the form of “club hair,” which is identifiable by its distinctive crumpled, brush-like appearance at the base. Shedding is believed to be an active process influenced by specific signals that disrupt the adhesion of the club hair to surrounding ...
In conclusion, available data strongly support the idea that follicular epithelial stem cells reside in the bulge, and that such stem cells can give rise to not only all the components of the hair shaft, but also the epidermis and the sebaceous gland. What is needed is a better understanding...
n, 3D reconstructed IF images of Survivin in GFP labeled-HFSCs after HC induction. Perpendicular cell division patterns are subdivided as inner cell division and surface cell division. o, The frequency of type of cell division (n = 17 HFs) in (n). p, 3D reconstructed IF images of ...
hairs cover thescalp. The eruption of hairs follows a cephalocaudal gradient over the body. During the later stages of hair formation, the hair bulb becomes infiltrated withmelanocytes, which provide color to the hair. Starting around the fifth month, the epidermal cells of the hair shaft begin...
The hair follicle is a skin accessory organ that regulates hair development, and its activity varies on a regular basis. However, the significance of metabolites in the hair follicle cycle has long been unknown. Targeted metabolomics was used in this inv
Disabled 2 (Dab2), an adaptor protein, is up regulated in the hair follicle stem cells (HFSCs); however, its role in any tissue stem cells has not been studied. In the present study, we have reported that Dab2 conditional knockout (Dab2-cKO) mice exhibit
Nodes represent the 29 genes associated with HFSCs and hair shaft growth and the nine candidate miRNAs that target them, which are connected by the edges.Figure 5 miR-22-5p inhibits hair follicle stem cell (HFSC) proliferation by targeting LEF1. A. CCK-8 was used to detect the effect ...
Matrix cells envelop the DP at the HF base and then rapidly proliferate and differentiate upward into one of the seven distinct layers of the hair shaft (HS), the inner root sheath (IRS), or the companion layer between the IRS and the ORS (Adam et al., 2018, Hsu et al., 2011, ...
Fig. 3.2.Schematic diagram of neurotransmitter mechanisms associated with type 1 and type 2 hair cell-vestibular afferent-vestibular efferent transmission. Receptor types are indicated by labeled rectangles in the appropriate elements. AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid), NMDA...
(H) Summary diagram of Wnt expression in anagen hair follicles. WNT responsive cells are shown in black and include precursor cells of the hair shaft cortex and cuticle (DasGupta and Fuchs, 1999, Millar et al., 1999) (solid black) and a subset of outer root sheath cells lying above the...