SIRT1是依赖于NAD+的蛋白脱乙酰化酶.SIRT1可以对组蛋白和p53,叉头(Fox)转录因子,Ku70,过氧化物酶体增殖激活受体γ(PPARγ),PPARγ共激活因子-1α(PGC-1α),核因子κB(NF-κB),真核翻译起始因子2α(EIF2α),热休克因子1(HSF1)等非组蛋白进行脱乙酰化,从而参与代谢,DNA修复,基因组稳定性,细胞周期,细胞...
The purpose of this study was to explore the effect of miR-34c on PDGF-BB-induced HAVSMCs phenotypic transformation and proliferation via PDGFR-β/SIRT1 pathway, so as to find a new method for early diagnosis and treatment of cardiovascular disease. HA-VSMCs were treated with platelet-...
成都紫苹果别墅设计,上海紫苹果装饰有限公司成都分公司。成都紫苹果别墅设计的抖音主页、视频、合集以及作品的粉丝量、点赞量。来抖音,记录美好生活!
FA-HA-Amygdalin@Fe2O3 and/or γ-rays affecting SIRT1 regulation of YAP/TAZ-p53 signaling and modulates tumorigenicity of MDA-MB231 or MCF-7 cancer cellsdoi:10.2174/1568009622666220816123508Abdel-RafeiAskarAzab
AMPK and SIRT1 followed by mitochondrial gene transcriptional co-activator PGC1α. The expression of mitochon-drial transcription factors Tfam and Nrf1 were also reduced confirming perturbation in mitochondrial function affecting low ATP production compared to control. This was also supported by the ...