SIRT1/FOXO1 signaling pathwayTaohong Siwu Decoction can reduce cerebral ischemia-reperfusion injury through anti-oxidative stress injury.Taohong Siwu Decoction can enhance autophagy, inhibit apoptosis and reduce cerebral ischemia-reperfusion injury.Taohong Siwu Decoction can modulate SIRT1/FOXO1 signaling ...
does not function as a MEF2 deacetylase. Instead, the NAD+-dependent deacetylase SIRT1 can potently induce MEF2 deacetylation. Our studies reveal a novel regulation of MEF2 transcriptional activity by two distinct classes of deacetylases that affect MEF2 sumoylation and acetylation. Authors Xuan Zhao,...
AMP-activated protein kinase (AMPK)/silencing information regulator (SIRT)1 signaling pathway plays an important role in MAFLD development. Si-Ni-San (SNS), a traditional Chinese medicine, has shown reducing hepatic lipid deposition in MAFLD rats, however, the underlying mechanisms of SNS are ...
1 and reduced the ratio of acetylated NF-κB and NF-κB by activating the circ-Sirt1/Sirt1 axis,which inhibited oxidative stress and inflammation in vivo and in vitro.Diosmetin reversed the effects of si-circSirt1 and si-Sirt 1 in LPS-treated Caco-2 and IEC-6 cells.When the gut ...
si-RNA-mediated silencing of caspase-9, but not of caspase-2, reduces Sirt1 cleavage.Giuseppa, PistrittoVeruska, PapaleoPilar, SánchezClaudia, CeciMaria, Luisa Barbaccia
Resveratrol-mediated SIRT-1 interactions with p300 modulate receptor activator of NF-κB ligand (RANKL) activation of NF-κB signaling and inhibit osteoclastogenesis in bone-derived cells. J Biol Chem. 2011; 286 :11492–505.Shakibaei M, Buhrmann C, Mobasheri A. Resveratrol-mediated SIRT-1 ...
Sugden MC, Holness MJ. Metformin, metabolic stress, and mitochondria. Focus on "A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells". Am J Physiol Cell Physiol 2012; 303:C1-3....
In vivo experiments investigated changes in the Sirt-1 signaling pathway post-SCI, while in vitro studies examined the effects of resveratrol on BM-MSCs under inflammatory conditions. The assessment included recovery of motor function, neuronal survival, and apoptosis in SCI rats treated with ...
Western blot tested the expression of ACE2/STAT3/PIM1 signaling‐associated factors. At the cellular level, LPS was used to induce lung epithelial cells BEAS‐2B to establish cell injury models. SIRT6 was overexpressed and ACE2 expression was inhibited by cell transfection, and the mechanism of...
GW28-e0612 Liver X receptor agonist T0901317 ameliorates sepsis-induced myocardial injury and dysfunction: the role of SIRT1 signalingdoi:10.1016/j.jacc.2017.07.067HEARTdiseasesECHOCARDIOGRAPHYHEARTinjuriesIMMUNOSTAININGWESTERNimmunoblottingDongHanJiangwei...