GzmBW/W CD8 T cells are unable to lyse MCMV infected cells.Christopher, E. AndoniouVivien R., SuttonMatthew, E. WikstromPeter, FlemingKevin, Y. T. ThiaAntony, Y. MatthewsDion, KaisermanIona, S. SchusterJerome, D. CoudertPreethi, Eldi...
CCR8-expressing regulatory T cells (Tregs) are selectively localized within tumors and have gained attention as potent suppressors of anti-tumor immunity. This study focused on CCR8 + Tregs and their interaction with CD8 + T cells in the tumor microenvironment of human lung cancer. We evaluated...
Correction to: Tcf1 protects antitumor TCRengineered CD8+ Tcells from GzmB mediated selfdestructiondoi:10.1007/s00262-022-03233-1Cancer Immunology, Immunotherapy -Zangari, BrendanDepartment of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, USA...
Further investigation indicated that NK cells, but not CD8(+) T cells, were the major sources of GrzB, and miR-378, but not miR-27a* or miR-30e, suppressed GrzB expression in NK cells. Notably, we found that overexpression of miR-378 using a miR-378 agomir in DENV-infected mice ...
Further investigation indicated that NK cells, but not CD8(+) T cells, were the major sources of GrzB, and miR-378, but not miR-27a* or miR-30e, suppressed GrzB expression in NK cells. Notably, we found that overexpression of miR-378 using a miR-378 agomir in DENV-infected mice ...
2003. Detection of low-frequency antigen-specific IL-10-producing CD4(+) T cells via ELISPOT in PBMC: cognate vs. nonspecific production of the cytokine. J. Immunol. Methods. 279: 111-121.3. Kreher, C.R., et al. 2003. CD4+ and CD8+ cells in cryopreserved human PBMC maintain full ...
Constitutive TCF-1B expression improved the survival of TCR-engineered CD8 + T cells upon engagementwith tumor cells. Tcf-1B prohibited the acquisition of a GzmB High state, and protected T cells from apoptosis associated with elicitation of effector function, and promoted stem cell-like ...
The article Tcf1 protects antitumor TCRengineered CD8+Tcells from GzmB mediated selfdestruction, writ ten by Brendan Zangari, Takemasa Tsuji, Junko Matsuzaki, Hemn Mohammadpour, Cheryl Eppolito, Sebastiano Battag lia, Fumito Ito, Thinle Chodon, Richard Koya, A. J. Robert McGray and Kunle ...
CD8+ lymphocytesProgrammed cell death ligand-1Granzyme B (GZMB) is a serine protease produced by cytotoxic lymphocytes that reflects the activity of anti-tumor immune responses in tumor-infiltrating lymphocytes (TILs); however, the prognostic significance of GZMB+ TILs in lung adenocarcinoma is poorly...
Constitutive TCF-1B expression improved the survival of TCR-engineered CD8 + T cells upon engagement with tumor cells. Tcf-1B prohibited the acquisition of a GzmB High state, and protected T cells from apoptosis associated with elicitation of effector function, and promoted stem cell...