In this issue of Blood, Gatza and colleagues demonstrate in a murine model of GVHD that ECP induces increases in circulating endogenous Tregs. Graft-versus-host disease (GVHD) remains one of the most frequent and challenging complications faced by allogeneic stem cell transplantation clinicians.1 Whi...
skin cGVHDtopical careChronic graft﹙ersus﹉ost disease (cGVHD) represents the major cause of late non‐relapse mortality and impaired quality of life. Human leukocyte antigen mismatch is the determinant of graft﹙ersus﹉ost disease (GVHD) occurrence, but minor histocompatibility antigens play a ...
Limited sclerotic cGVHD of the skin without any functional impact presents a similar challenge. Disease activity and scoring system How does our scoring system account for long-term survivors with permanent sequelae of cGVHD, without any major functional impact and off all immunosuppression? In other ...
The skin is a frequently involved organ in graft-versus-host disease(GVHD). Various skin lesions including erythematous eruption, bullae, desquamation, lichenoid, and sclerodermoid lesions have been reported in GVHD, but vitiligo-like lesions were. We present two cases of chronic GVHD presenting ...
But the clinical constellation of symptoms that this patient has defines this as chronic GvHD with lichenoid changes in the mouth, the skin, the nail bed, and the joint involvement. All of those factors together make this chronic graft-versus-host disease. Chronic GvHD occurs between 20% and ...
EP: 1.Acute Versus Chronic Graft-Versus-Host Disease (GVHD) EP: 2.Phases of Pathophysiology of Chronic GVHD EP: 3.Monitoring Patients with GVHD EP: 4.Expectations of Chronic GVHD Treatment EP: 5.Targeted Treatments for GVHD EP: 6.Corticosteroids and Clinical Trial Design in Chronic GVHD EP:...
Barnes and Loutit first described (in mice) what is now known as graft versus host disease (GVHD) as a syndrome called secondary disease to differentiate it from primary disease of radiation sickness. Mice that were given allogeneic spleen cells after ir
Graft versus host disease (GVHD) is a common complication following allogeneic hematopoietic cell transplantation (HCT) that typically manifests as injury to the skin, gastrointestinal mucosa, and liver. In some cases, hepatic GVHD may be histologically indistinguishable from other disorders such as inf...
可以使用生物标志物来确定gvhd的具体起因,诸如,皮肤中的弹性蛋白酶抑制剂(elafin)(paczesny,s.;levine,j.e.;hogan,j.;crawford,j.;braun,t.m.;wang,h.;faca,y.;zhang,q.etal.(2009).“elafinisabiomarkerofgraftversushostdiseaseoftheskin”.biologyofbloodandmarrowtransplantation15(2):13-4)。慢性移植...
Chronic graft-versus-host disease (GVHD) threatens patient-reported quality of life (QOL) after allogeneic hematopoietic cell transplantation. However, the sensitivity of serially assessed chronic GVHD severity to change in QOL has not been determined. We examined the sensitivity of changes in chronic...