我校张和平教授团队在《Gut Microbes》期刊发表益生菌临床研究重要成果 12月9日,我校作为第一完成单位,与南方医科大学深圳医院联合完成的研究成果“自闭症谱系障碍儿童肠道失调的组学特征:通过益生菌和中等碳水化合物饮食干预联合缓解自闭症...
However, findings in human studies are less abundant. Although there are several studies so far showing altered microbiota (dysbiosis) in ASD, the results are heterogeneous and often contradictory. Intervention studies such as fecal microbiota transplant therapies show promise and lend credence to the ...
ASD患儿的肠道菌群发育逐渐偏离正常轨道:α多样性持续较低、早期菌群持续不稳定不成熟、常见菌属检出率较低(提示其定植有困难)、3岁前的细菌间关系明显改变、20个OTU丰度和325个菌群代谢功能改变,且变化模式具有年龄依赖性;③ 多个OTU、菌群功能及细菌关系的变化,与行为、睡眠和胃肠症状严重程度...
2022). Evidence suggests that Long COVID patients often have abdominal discomfort and dysbiosis (Hilpert and Mikut 2021). Gut dysbiosis can cause changes in blood metabolites such as amino acids, fatty acids, and bile acids, which may contribute to systemic inflammation in Long COVID patients (...
Genetically or environmentally manipulated rodent models of autism have furthered our understanding of molecular mechanisms through which microbial dysbiosis in ASD affects animal behaviors [73]. Using known mouse models of ASD (e.g., MHFD), researchers can apply top-down approaches to study if the...
2d), while TMA in stool trended in the same direction but did not reach statistical significance (Fig. 2c). Patient factors associated with dysbiosis Important factors specific to FD and/or FD treatment likely contributed to differences in microbiome and metabolome diversity between FD patients ...
(ASD) research, particularly focusing on microbiome dysbiosis and probiotics as potential interventions. This abstract explores the interplay between and the mechanisms of action. Individuals with ASD commonly exhibit gut microbiome alterations, implicating dysbiosis in ASD pathogenesis. Probiotics, which are...
Dysbiosis (an imbalance in the gut microbiome) has been linked to altered immune responses that may disrupt brain function and contribute to neurological and psychiatric disorders [40]. 2.4.3. Gut–Immune–Brain Communication Immune cells in the gut can communicate directly with the brain via the...
et al. Dysbiosis of microbiome and probiotic treatment in a genetic model of autism spectrum disorders. Brain Behav. Immun. 73, 310–319 (2018). PubMed Google Scholar Needham, B. D. et al. Plasma and fecal metabolite profiles in autism spectrum disorder. Biol. Psychiatry https://doi.org...
in the acute and chronic phases of COVID-19. Gut dysbiosis is not limited to GI disturbances but also leads to enhanced production of inflammatory cytokines and lack of nutrients triggering a systemic inflammatory response mainly observed in post-viral sequelae. In this context, the current role ...