However, findings in human studies are less abundant. Although there are several studies so far showing altered microbiota (dysbiosis) in ASD, the results are heterogeneous and often contradictory. Intervention studies such as fecal microbiota transplant therapies show promise and lend credence to the ...
A recent Chinese study has shown that autism spectrum disorder is associated with dysbiosis in the gut microbiome, offering reference for future therapeutic plans. ASD is a neurodevelopmental disorder that may be influenced by both environmental and genetic factors. Previous studies have found that gut...
ASD患儿的肠道菌群发育逐渐偏离正常轨道:α多样性持续较低、早期菌群持续不稳定不成熟、常见菌属检出率较低(提示其定植有困难)、3岁前的细菌间关系明显改变、20个OTU丰度和325个菌群代谢功能改变,且变化模式具有年龄依赖性; 多个OTU、菌群功能及细菌关系的变化,与行为、睡眠和胃肠症状严重程度相关;...
model, and that cohousing mutant and littermate control mice ameliorates gut microbiome dysbiosis, improves deficits in gut transit, and reduces disease severity. Our results provide evidence that neurologic deficits in FD alter the structure and function of the gut microbiome, which shifts overall hos...
12月9日,我校作为第一完成单位,与南方医科大学深圳医院联合完成的研究成果“自闭症谱系障碍儿童肠道失调的组学特征:通过益生菌和中等碳水化合物饮食干预联合缓解自闭症症状的临床研究”(Omic characterizing and targeting gut dysbiosis in ch...
Gut dysbiosis was more frequent in AS than controls (36% versus 17%, p=0.023), while nr-axSpA (25% dysbiosis) did not differ significantly from either AS or controls. Univariately, most axSpA measures were significantly worse in patients with dysbiosis versus those without: ASDAS-CRP between...
It is now well established that autism spectrum disorder (ASD) is associated with dysbiosis in thegut, and, indeed, this is viewed by many as an important contributor to ASD. The study cited is byKaroly Horvath, who has pushed the connection between "leaky gut" and autism, similar to Andr...
It is well known that dysbiosis of the GI tract could lead to inflammation and immune activation in several pathologies [15]. The frequent occurrence of GI symptoms in autistic subjects imply the possible involvement of the gut microbiota in ASD gastrointestinal pathophysiology, further supported by ...
While ASD is different from MS, PD and AD in that it primarily involves CNS developmental issues rather than an ongoing inflammatory disease, a significant body of literature indicates an active role of dysbiosis in ASD. Some ASD patients report GI problems, such as abdominal pain, diarrhea, an...
In this paper, we review the dysbiosis of gut microbiota and the corresponding mechanisms in the common neuropsychiatric diseases, and looks forward to its potential role in the diagnosis and treatment of neuropsychiatric diseases in the future....