The effects of human-targeted drugs on gut bacteria are reflected on their antibiotic-like side effects in humans and are concordant with existing human cohort studies. Susceptibility to antibiotics and human-targeted drugs correlates across bacterial species, suggesting common resistance mechanisms, which...
S. Evolutionary dynamics of bacteria in the gut microbiome within and across hosts. Preprint at https://doi.org/10.1101/210955 (2017). Ahern, P. P., Faith, J. J. & Gordon, J. I. Mining the human gut microbiota for effector strains that shape the immune system. Immunity 40, 815–...
In humans, about a dozen metagenomic studies on various populations across the world have identified substantial changes in abundance of specific bacteria9,10,11,12,13,14,15,16. Meta-analyses of these datasets have identified globally cross-cohort microbial signatures that can predict CRC at high ...
Bacterial activation of Th17 cells exacerbates mouse models of autoimmunity; yet, the diverse mechanisms of how autoimmune-associated bacteria contribute to Th17 activation and disease are still being elucidated. Seminal work revealed that segmented filamentous bacteria (SFB) increase Th17 cells in mice ...
What's more, the transplant altered the metabolism of the mice: animals that received gut bacteria from an obese person had metabolic changes linked with obesity in humans (such as increased production of compounds called branched-chain amino acids); while those that received gut bacteria from a...
The community of microbial cells in the human gut is estimated to be comparable in magnitude to the number of human cells1. This community, deemed the human gut microbiome, is mainly composed of bacteria, archaea, fungi, and viruses, with bacteria being the largest constituent. These bacterial...
Here, we focus on the familyChristensenellaceae, within theFirmicutesphylum ofBacteria, due to its emergence as a health-related group. First encountered from 16S rRNA gene sequences alone, the family was named in 2012 after an isolate namedChristensenella minuta(pictured in Fig.1), cultivated ...
Nevertheless, our understanding of how gut bacteria modulate the immune system remains limited, particularly in humans, where the difficulty of direct experimentation makes inference challenging. Here we study hundreds of hospitalized—and closely monitored—patients with cancer receiving haematopoietic cell ...
WASHINGTON, March 8 (Xinhua) -- Bacteria found in the small intestines of mice and humans can travel to other organs and trigger an autoimmune response, according to a new study published on Thursday in the journal Science. The findings suggested promising new approaches for treating chronic auto...
Malaria is caused by Plasmodium species and remains a significant cause of morbidity and mortality globally. Gut bacteria can influence the severity of malaria, but the contribution of specific bacteria to the risk of severe malaria is unknown. Here, mul