大家好,今天为大家分享一篇发表在Science上的文章,文章的题目是“The G protein signaling regulator RGS3 enhances the GTPase activity of KRAS”。文章通讯作者是斯隆-凯特琳癌症中心的Piro Lito教授,其课题组专注于研究肺癌和其他实体瘤相关的调节机...
Polypeptide having a gtpase regulator activity, nucleic acids coding therefor and their use in diagnostics and therapyThe present invention discloses a polypeptide which is a GTPase regulator associated with focal adhesion kinase comprising the amino sequence FRITZ LAMPERTARNDT BORKHARDT ...
近日，来自美国纪念斯隆凯特琳癌症中心的Piro Lito团队在Science杂志上发表了一篇题为 The G protein signaling regulator RGS3 enhances the GTPase activity of KRAS 的文章，这项研究报道了RGS3，一种先前已知的用于调节G蛋白偶联受体的GAP，可以以不依赖于传统催化精氨酸残基的方式同时增强突变型和野生型KRAS蛋白的G...
近日,来自美国纪念斯隆凯特琳癌症中心的Piro Lito团队在Science杂志上发表了一篇题为The G protein signaling regulator RGS3 enhances the GTPase activity of KRAS的文章,这项研究报道了RGS3,一种先前已知的用于调节G蛋白偶联受体的GAP,可...
Name : Recombinant Human MORF4L2 protein ,C- His TagBackground : Background : Biological Activity... Post Categories Uncategorized Post dateMay 25, 2024Post last updated dateUpdated May 25, 2024 Recombinant Human MOG protein ,C- His Tag Post author GTPase atpasePost read time1 min read ...
membrane of root hairs and interacts with the tip-growth regulator ARMADILLO REPEAT ONLY PROTEINs (AROs)26,27, implying its potential function as a local inactivator. In Arabidopsis, only two RopGAPs are detectable in pollen tubes. However, their loss of function does not cause discernable ...
the p-LAT Y171 signal relative to the expression of LAT confirmed that the phosphorylation of LAT at Y-171 was reduced by ~50% (histogram, lower panel). Overall, these data showed that Rasal1 can bind to the kinase domain of ZAP-70, and in the process, inhibit its catalytic activity....
We demonstrate that Rheb GTPase (Ras homolog enriched in brain), which induces mammalian target of rapamycin (mTOR) activity, is a physiological regulator of BACE1 stability and activity. Rheb overexpression depletes BACE1 protein levels and reduces Aβ generation, whereas the RNAi knockdown of ...
cofilin, a regulator of actin dynamics enriched in developing axons (Garvalov et al., 2007). This phosphorylation is achieved by LIMK, an activity stimulated by a cdc42 effector kinase, Pak1. Paradoxically, Pak1 activity is greatly reduced in cdc42-null mice, suggesting that the deregulation ...
A mutant form of the Ran/TC4 protein disrupts nuclear function in Xenopus laevis egg extracts by inhibiting the RCC1 protein, a regulator of chromosome condensation. EMBO J. 13, 5732–5744 (1994). CAS PubMed PubMed Central Google Scholar Nicolás, F. J. et al. Xenopus Ran-binding ...