Both proteins undergo significant conformational changes on binding, to form a new type of G-protein/effector complex. The interaction extends the beta-sheet in Cdc42 by binding an extended strand from ACK, as seen in Ras/effector interactions, but it also involves other regions of the G ...
Rab-GTPase binding effector protein 2 (RABEP2) was identified as a novel GSK3 substrate and GSK3 phosphorylation of RABEP2 at Ser200 was enhanced by prior phosphorylation at Ser204, fitting the known consensus sequence for GSK3 substrates. Both residues are phosphorylated in cells while only ...
Small GTP-binding proteins regulate diverse processes in eukaryotic cells such as signal transduction, cell proliferation, cytoskeletal organization, and intracellular membrane trafficking. These proteins function as molecular switches that cycle between "active" and "inactive" states, and this cycle is lin...
The septins are a conserved family of GTP-binding, filament-forming proteins. In the yeast , the septins form a ring at the mother-bud neck that appears to... Caviston,P J. - 《Molecular Biology of the Cell》 被引量: 515发表: 2003年 Interaction of Rac1 with GTPase-activating proteins...
除此之外还有其他功能:如最近发现,Ran GTPase在细胞有丝分裂过程起着重要作用,因为Ran-结合蛋白(Ran binding protein,Ran-BP),如 RanBPM(Ran binding protein in microtubule organ-ziting center)定位在中心体上,而中心体是有丝分裂纺锤体的生长点。体外使用非洲爪蟾属的未受精卵细胞系统检验发现,Ran 在不同形式...
H. A putative GTP binding protein homologous to interferon-inducible Mx proteins performs an essential function in yeast protein sorting. Cell 61, 1063–1074 (1990). Article CAS PubMed Google Scholar Yarar, D., Waterman-Storer, C. M. & Schmid, S. L. A dynamic actin cytoskeleton functions...
Binding of the Rags to p18 was analysed by immunoblotting. f, Quantification of relative Rag-p18 binding. n = 3 independent experiments. g, Working model for the differential regulation of mTORC1 by RagC- or RagD-containing dimers. RagD-containing dimers show stronger binding to p18/...
The GTPase activity of YeiR is similar to that measured for other members of the group, but GTP hydrolysis is enhanced by Zn2+binding. These results support the predicted connection between the COG0523 P-loop GTPases and roles in metal homeostasis. 展开 ...
展开 关键词: Humans Cells, Cultured Hela Cells Cell Nucleus Guanine Nucleotide Exchange Factors Monomeric GTP-Binding Proteins rhoA GTP-Binding Protein RNA, Small Interfering Oncogene Proteins Signal Transduction DOI: 10.1371/journal.pone.0017380 被引量: 89 年份...
[摘要]核内小分子GTP结合蛋白(asmallnuclearGTP-bindingprotein,Ran)是一种分 布于真核细胞核内含 量十分丰富的小分子GTP酶,是Ras基因大家族中的一员.Ran具有多种生物学功 能,参与调节核物质转 运,调控核膜装配,纺锤体组装,DNA复制,RNA转录,加工和运输,细胞周期及LPS ...