Structure of Cdc42 bound to the GTPase binding domain of PAK . Nat. Struct. Biol. 7 : 384 – 388 .Morreale A et al ( 2000 ) Structure of Cdc42 bound to the GTPase binding domain of PAK . Nat Struct Biol 7 : 384 – 388
Binding of the Rags to p18 was analysed by immunoblotting. f, Quantification of relative Rag-p18 binding. n = 3 independent experiments. g, Working model for the differential regulation of mTORC1 by RagC- or RagD-containing dimers. RagD-containing dimers show stronger binding to p18/...
3. Nordmann, M., et al., The Mon1-Ccz1 complex is the GEF of the late endosomal Rab7 homolog Ypt7. Curr Biol, 2010. 20(18): p. 1654-9.4. Klink, B.U., et al., Structure of the Mon1-Ccz1 complex reveals molecular basis of membrane binding for Rab7 activation. Proc Natl Aca...
The Wiskott– Aldrich syndrome protein, WASP, which has a pleckstrin-homology domain and a Cdc42/Rac-binding motif, has been implicated in cell signaling... Flavia,Castellano,and,... - 《Current Biology》 被引量: 310发表: 1999年 The Cdc42-selective GAP Rich regulates postsynaptic development...
IgG labeling reagent utilizes a pH-sensitive fluorescently labeled Fc binding protein to bind to IgG antibodies to measure antibody internalization activity. View Products NewEast Products Classification Rabbit and Mouse Monoclonal Antibodies Specific Antibodies Only to Bind GTP-bound G Proteins (Not GDP-...
11. Lin T, Zeng L, Liu Y, et al. Rho-ROCK-LIMK-cofilin pathway regulates shear stress activation of sterol regulatory element binding proteins. Circ Res. 2003;92(12):1296-1304. 12. Feng D, Wang J, Yang W, et al. Regulation of Wnt/PCP signaling through p97/VCP-KBTBD7-mediated Va...
‘exchange’ GTP into a binding pocket previously occupied by GDP, hence turning ‘on’ the GTPase.GTPase-Activating-Proteins (GAPs) activate the intrinsic GTPase activity of these proteins (speeding up the timer), and convert bound GTP into GDP and turn ‘off’ the switch. It is the ...
11. Lin T, Zeng L, Liu Y, et al. Rho-ROCK-LIMK-cofilin pathway regulates shear stress activation of sterol regulatory element binding proteins. Circ Res. 2003;92(12):1296-1304. 12. Feng D, Wang J, Yang W, et al. Regulation of Wnt/PCP signaling through p97/VCP-KBTBD7-mediated Va...
We therefore evaluated the ability of Wrch-1 to interact with its best-validated effector, PAK, at each of these locations, by utilizing a GFP-tagged form of the GTPase-binding domain of PAK (GFP-PAK-PBD). To test whether the same conditions of serum stimulation that cause Wrch-1 to ...
Rab-GTPase binding effector protein 2 (RABEP2) was identified as a novel GSK3 substrate and GSK3 phosphorylation of RABEP2 at Ser200 was enhanced by prior phosphorylation at Ser204, fitting the known consensus sequence for GSK3 substrates. Both residues are phosphorylated in cells while only ...