Role and Biological Significance of GSK-3β Signal Pathway in Alzheimer’s Disease XU Yong1, WANG Hao2,†, ZHANG Jiguo2 Author information+ 文章历史+ 摘要 糖原合成酶激酶-3β(GSK-3β)为存在于真核细胞内的多功能丝氨酸/苏氨酸蛋白激酶,广泛表达于哺乳动物的肌肉、脂肪、肝脏和脑等组织中。GSK-3...
Pharmacological inhibitors or HMGB1 knockdown inactivated the GSK-3 beta/beta-catenin pathway, inhibited the expression levels of downstream genes, including MMPs and ADAMTS, and attenuated the apoptosis of ATDC5 cells. Furthermore, the data demonstrated that HMGB1 promoted chondrocyte dysfunction via ...
Human embryonic and induced pluripotent stem cells are self-renewing pluripotent stem cells (PSC) that can differentiate into a wide range of specialized cells. Basic fibroblast growth factor is essential for PSC survival, stemness and self-renewal. PI3K
Enteric glial cells protect neurons against high glucose-induced injury in part via the activation of Akt/GSK-3beta pathway BACKGROUND: The mechanism of electroacupuncture on multi-acupoints in the treatment of peripheral facial paralysis is still unknown. Glial cell-derived neu... M Chang,L Pan...
In this study, we identified Glycogen Synthase Kinase 3 beta (GSK3), a negative regulator of Wnt signal pathway, participated in ameloblast differentiation via Wnt and TGF- pathways during enamel development. In vitro rat mandible culture treated with specific GSK3 inhibitor SB415286 displayed ...
The NF-E2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway plays a critical role in protecting against oxidative stress in brain ischemia and reperfusion injury. Glycogen synthase kinase 3β (GSK-3β) may play a critical role in regulat
The phosphoinositide 3-kinase/Akt/glycogen synthase kinase-3 beta (GSK-3β) and Wnt/β-catenin pathways are dysregulated in a number of cancers, and these two pathways share a common node protein, GSK-3β. This protein is responsible for the regulation/degradation of β-catenin, which ...
Fig.3 GSK3β/NF-κB pathway ②GSK3β调控其他信号通路。除NF-κB 通路,GSK3β促癌作用也与其他机制有关。在非小细胞肺癌[12]中,敲低GSK3β基因后不同非小细胞肺癌细胞系中NF-κB表达水平不一,表明GSK3β介导的肿瘤调节与NF-κB通路无关,而其移植瘤模型显示GSK3β促癌机制可能与Ki-67通路调节相关;一...
Conclusion LiCl may cause HK-2 cell cycle arrest in G2 phase through activation of the AKT/GSK-3β signaling pathway. Key words: lithium chloride AKT/GSK-3β HK-2 cells cell cycle 肾间质纤维化是各种肾脏病缓慢进展至终末期肾病的最后通路,而近端肾小管上皮细胞肥大、上皮间充质转分化(EMT)、...
Explore the GSK3 signaling pathway and find antibodies to detect some of its target proteins, including beta-catenin, GSK, CD324 (E-cadherin), and CD144 (VE-cadherin).