~46 kDa (beta) and 51 kDa (alpha) Immunogen: N-terminal 6His-tagged recombinant full length human GSK3β. Isotype: IgG Background Information: Glycogen Synthase Kinase 3 differs from most serine/threonine kinases in that it is active in the absence of the action of signaling pathways. Two...
Furthermore, ISO increased the level of phosphorylated GSK-3 beta, the upstream molecule of Nrf2. In conclusion, these results indicated that ISO might exhibit its anti-inflammatory effects through activating GSK-3 beta-Nrf2 signaling pathway....
MiR-155/GSK-3β signaling pathway involved in the activation of LPS-induced RAW264.7 cells Studies have shown that miR-155 can inhibit the expression of GSK-3β by directly binding with the 3′noncoding region of GSK-3β mRNA15,16. It is highly probable that GSK-3β is one downstream ...
Function: Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC...
Function: Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC...
SIRT7 antagonizes TGF-beta signaling and inhibits breast cancer metastasis. Nat. Commun. 8, 318 (2017). Article ADS PubMed PubMed Central CAS Google Scholar Wang, L. FKBP51 regulation of AKT/protein kinase B phosphorylation. Curr. Opin. Pharmacol. 11, 360–364 (2011). Article CAS Pub...
Chou CH;Chou AK;Lin CC;.GSK3betaregulates Bcl2L12 and Bcl2L12A anti-apoptosis signaling in glioblastoma and is inhibited by LiCl.Cell Cycle.2011.532-542Chou CH, Chou AK, Lin CC, Chen WJ, Wei CC, Yang MC, Hsu CM, Lung FW, Loh JK, Howng SL, Hong YR. GSK3beta regulates Bcl2L12...
Function:Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC,...
Function: Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC...
Excessive activation of GSK-3β has negative effects in neurodegenerative diseases. For example, hyperactive GSK-3β promotes tau phosphorylation and amyloid beta deposition in AD [23] and facilitates neuronal death in MPP+, rotenone, or 6-hydroxydopamine-induced in vitro PD models [24,25]. More...