glycogen synthase kinase 3 beta 研究领域 Notch Pathway 相关通路图 Canonical Wnt Pathway NF-kB (NFkB) Pathway p53 Pathway AKT Signaling Pathway AMPK Signaling Pathway B Cell Receptor Signaling Pathway MAPK-Erk Pathway IL17 signaling pathway
glycogen synthase kinase 3 beta Research Areas Notch Pathway Related Pathways Canonical Wnt Pathway NF-kB (NFkB) Pathway p53 Pathway AKT Signaling Pathway AMPK Signaling Pathway B Cell Receptor Signaling Pathway MAPK-Erk Pathway IL17 signaling pathway ...
Two isoforms, alpha (GSK3A; MIM 606784) and beta, show a high degree of amino acid homology (Stambolic and Woodgett, 1994 [PubMed 7980435]). GSK3B is involved in energy metabolism, neuronal cell development, and body pattern formation. Participates in the Wnt signaling pathway. Implicated ...
~46 kDa (beta) and 51 kDa (alpha) Immunogen: N-terminal 6His-tagged recombinant full length human GSK3β. Isotype: IgG Background Information: Glycogen Synthase Kinase 3 differs from most serine/threonine kinases in that it is active in the absence of the action of signaling pathways. Two...
Function: Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC...
Function:Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), EIF2B, CTNNB1/beta-catenin, APC,...
(GSK 3A) and beta, show a high degree of amino acid homology. GSK 3B is involved in energy metabolism, neuronal cell development, and body pattern formation. GSK 3B participates in the Wnt signaling pathway and has been implicated in the hormonal control of several regulatory proteins including...
MiR-155/GSK-3β signaling pathway involved in the activation of LPS-induced RAW264.7 cells Studies have shown that miR-155 can inhibit the expression of GSK-3β by directly binding with the 3′noncoding region of GSK-3β mRNA15,16. It is highly probable that GSK-3β is one downstream ...
Furthermore, ISO increased the level of phosphorylated GSK-3 beta, the upstream molecule of Nrf2. In conclusion, these results indicated that ISO might exhibit its anti-inflammatory effects through activating GSK-3 beta-Nrf2 signaling pathway....
Taken together, these results suggest that HSYA protects against cerebral I/R injury partly by reducing apoptosis via PI3K/Akt/GSK3 beta signaling pathway. 展开 关键词: GLYCOGEN-SYNTHASE KINASE-3 ENDOTHELIAL-CELLS NEURONAL SURVIVAL UP-REGULATION EXPRESSION AKT PHOSPHORYLATION LOCALIZATION PROMOTES PI3K/...