在12-30周的治疗期间GS-441524的治疗非常安全,基本没有什么不良反应,内仅有一只例外,其在第三轮治疗的第八周出现尿素氮、SDMA突然升高,但症状轻微,出于安全,立即停止了药物治疗,此后1个月异常现象逐渐消退,目前猫的病情已得到缓解。 综上,GS-441524是一种安全有效的FIP治疗方法。治疗的较佳剂量为每24h皮下注射4.0...
19 European Advisory Board on Cat Diseases (ABCD).FIP DiagnosisTool.https://www. abcdcatsvets.org/wp-content/uploads/2022/11/TOOL_FIP_Feline_infectious_peritonitis_ December_2021_EN.pdf (2021, accessed 11 April 2023). 20 European Advisory Board on Cat Diseases (ABCD).Felinecoronavirus & felin...
本研究的目的是证明GS-441524治疗自然发生FIP的猫的安全性和有效性。像GS-441524这样的小分子药物重量为900道尔顿,大小约为1 nm,可以很容易地进入细胞并与关键靶分子相互作用。与已经发表的通过阻碍病毒复制所占用的细胞过程来抑制FIPV的物质或药物不同,[13,14]像GS-441524这样的小分子是直接干扰病毒编码的复制过程...
https://www.abcdcatsvets.org/guideline-for-feline-infectious-peritonitis/翻译: google翻译,winter喵校对译者注:本文对猫传腹(fip)的诊断,治疗,防范等进行了详尽的描述.文中有较多生物学术语,翻译尽量消除歧义,与原文意思一致,但是读起来可能会有些拗口.全文共1万1千字,涉及到许多知识点,如果某个知识点看不...
M, Pedersen NC. The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP...
GS-441524 是 Remdesivir 的主要活性代谢物,活性更优于 Remdesivir ,治疗患有自然发生的猫传染性腹膜炎的猫。 TargetMol的所有产品仅用作科学研究或药证申报,不能被用于人体,我们不向个人提供产品和服务。请您遵守承诺用途,不得违反法律法规规定用于任何其他用途。
描述: GS-441524 是 Remdesivir 的主要活性代谢物,活性更优于 Remdesivir ,治疗患有自然发生的猫传染性腹膜炎的猫。 动物实验: Cats ranged from 3.4-73 months of age (mean 13.6 months); 26 had effusive or dry-to-effusive FIP and five had non-effusive disease. Cats with severe neurological and oc...
a lethal systemic disease affecting domestic cats. Remdesivir was never tested in cats (though some vets now offer it), but GS-441524 has been found to be effective treatment for FIP and is widely used despite no official FDA approval due to Gilead's refusal to license this drug for veterin...
Animal Cats [1] Administration [1] The 10 cats that developed disease signs are divided into two groups and treated with either 5 mg/kg (Group A; n=5) or 2 mg/kg (Group B; n=5) GS-441524 SC q24 h starting three days after unequivocal clinical evidence of FIP (days 12-19 post...
GS-441524 is treated with 100, 33.3, 11.1, 3.7, or 1.2 μM for a 24-hour period on CRFK cells in order to assess its toxicity[1]. Animal Protocol Cats: Three days after unambiguous clinical evidence of FIP (days 12-19 post infection), the 10 cats that showed disease signs were spli...