(A) The structure of the ATP bound state of human GRP78 (PDB ID: 5E84) which contains two major functional domains the nucleotide binding domain (NBD; purple) and the substrate binding domain (SBD; grey and cornflower blue). These two domains are connected via the interdomain linker (...
Fig. 1. A) shows the x-ray apo form of GRP78 solved structure (PDB ID 6EOC) at 1.67 Å resolution. The protein is represented by cartoon colored green (NBD), red (SBD) and purple (linker). GRP78 sequence is represented also with the same color as the protein domains. B) ATP...
B) The predicted average binding affinity of AMP to the fungal CotH3 (green) and the bacterial CotH (red) apo structure (PDB ID: 5JDA). For CotH3 to be active as kinase AMP should be present in its position, we docked it using AutoDock Vina software. Fig. 2B shows the average ...
Potato Dextrose Broth 马铃薯葡萄糖肉汤(PDB) 250g 瓶 琼脂糖凝胶6B 英文: Sepharose 6B CAS号: GRP78葡萄糖调节蛋白78elisa试剂盒科研专用CCDC54/NYD-SP17 卷曲螺旋结构域蛋白54抗体 规格: 0.2ml MAP3K9 丝裂原活化蛋白激酶3K9抗体 规格: 0.2ml
The crystal structure of GRP78 was obtained from the Protein Data Bank (http://www.rcsb.org/pdb/) with the ID of 3LDP. The water molecules in GRP78 were removed. For docking purposes, the center of the binding site was determined by 3P1, an inhibitor of GRP78. The binding site was...
PDB: Protein data bank SDF: Structure data format MSA: Multiple sequence alignment MD: Molecular dynamics ns: Nanoseconds MM-PBSA: Molecular mechanics/Poisson−Boltzmann surface area References Goodenberger ML, Jenkins RB et al. (2012) Genetics of adult glioma. Cancer Genet 205(12):613...
(B) Accessibility of the client peptides from the peptide array at the TDP-43 surface (ASA) were calculated using Areaimol as implemented in the CCP4 suite35 on the free form structure of the tethered RRM domains (PDB ID 4 bs222). To note, there is no significant difference in...