【结论】 sGRP78能诱导NOD小鼠来源的DCs形成耐受,该细胞自体回输能缓解自发1型糖尿病的NOD小鼠的胰岛炎;腹腔注射sGRP78能缓解小鼠结肠炎,但促进小鼠结肠肿瘤的生长,可能机制为sGRP78通过活化STAT3促进B细胞表达PD-L1,发挥免疫调节功能.华中科技大学周晓琪
GRP78 (Glucose-related protein 78, BiP/HSPA5) is commonly overexpressed in cancer cells. Acting as an activator of endoplasmic reticulum stress, GRP78 is involved in the resistance of cancer cells to injury. Current evidence suggests that GRP78 plays a significant role in the radiotherapy resistan...
We have previously reported that secreted GRP78 (sGRP78) induced splenic B cells into regulatory IL-10+PD-L1hiFasLhi B cells [4], as well as BMDCs into tolerogenic DCs with low MHC-II expression and high levels of B7-H3, B7-H4 [5]. In addition, sGRP78 inhibited the release of ...
and endoplasmic reticulum stress (ERS) are very important pathological processes. Glucose regulated protein 78 (GRP78) and phosphorylated form of extracellular signal-regulated protein kinase (pERK) play important roles in it. This study aimed to investigate the expression of GRP78 and pERK in...
A PD-L1-targeting chimeric switch receptor enhances efficacy of CAR-T cell for pleural and peritoneal metastasis Signal Transduct. Targeted Ther., 7 (2022), p. 380 View in ScopusGoogle Scholar 34 E.A. Lafleur, N.V. Koshkina, J. Stewart, S.F. Jia, L.L. Worth, X. Duan, E.S. Kl...
We now show that CBT300's elimination of csGRP78 destabilizes and removes oncofetal proteins ROR1, and Cripto, and checkpoint protein PD-L1 from tumor cell surfaces resulting in reversal of chemoresistance, reduction in immune suppression, inhibition of stem cell phenotype and increased tumor ...