Serum leptin, a reflection of body fat, declined with growth hormone therapy in a dose-dependent manner in intrauterine growth retardation children; the magnitude of the decline correlated with linear growth response. Skin is a target organ for growth hor...
Purpose. We hypothesize that growth hormone (GH) plays a significant role in the regulation of the meibomian gland. To test our hypothesis, we examined the influence of GH on mouse meibomian gland structure. Methods. We studied four groups of mice, including (1) bovine (b) GH transgenic mic...
Human Growth Hormone (hGH) is another naturally occurring hormone that is made in the pituitary gland and plays a major role in stimulating growth in children and increasing muscle mass in adults. From: Encyclopedia of Mental Health (Third Edition), 2023 ...
The GH isoforms are carried in the circulation to target organs, where they bind to cell plasma membrane receptors (8). The full-length, high-affinity growth hormone receptor (GH-R) contains an extracellular hormone-binding domain, a transmembrane region, and a long cytoplasmic domain (9). Th...
Growth hormone (GH) secretion, either spontaneous or evoked by provocative stimuli, is markedly blunted in obesity. In fact obese patients display, compare... M Scacchi,AI Pincelli,F Cavagnini - 《Int J Obes Relat Metab Disord》 被引量: 615发表: 1999年 Growth hormone in obesity Growth horm...
comes to the dosage administered which are brutally over the target of restoring the physiological normal levels of the hormone. All studies have been conducted using 80 µg–4 mg/kg/day and ranging in a wide spectrum of lengths (weeks to months) and routes of administration. In all our ...
Hormone pathways also converge in the regulation of common targets. Interestingly, however, transcriptomic analysis using GA, IAA, and BRs has suggested that the exogenous applica- tion of each hormone regulates a set of specific target genes independently (Nemhauser et al., 2006). This finding ...
mammalian target of rapamycin (AMPK): AMP-activated protein kinase (ERK1/2): extracellular signal regulated kinase 1/2 (NF-kappa B): nuclear factor-kappa B (PKC): protein kinase C (SS): somatostatin (GHR): growth hormone receptor
Growth hormone secretagogues (GHSs) release growth hormone (GH) via both the hypothalamus and the pituitary gland, and also stimulate ACTH and prolactin release. The presence of a seven transmembrane, G protein-coupled specific receptor has been described (1) both in the hypothalamus and...
In two large European studies of growth hormone use in critically ill adults, patients treated with growth hormone had a 1.9- to 2.4-fold relative risk of mortality, mostly due to multiple organ dysfunction syndrome, shock, or uncontrolled infection. Growth hormone-treated patients also had ...