This chapter discusses the interactions of growth hormone (GH) with other hormones. GH exerts its multiple effects not on a target organ but on every cell of the organism. Therefore, it is expected that the action of GH depends on the metabolic equilibrium of each cell, which in turn is ...
Growth hormone (Growth Hormone, GH) is a peptide chain with two internal disulfide bridges formed by 191 amino acids with a molecular weight of 22,000 Da in humans. It is the hormone that stimulates the growth of tissues and organs during childhood and adolescence and remains important through...
Achieving normal growth is one of the most challenging problems in the management of children with chronic kidney disease (CKD). Treatment with recombinant human growth hormone (GH) promotes longitudinal growth and likely enables children with CKD and sh
The GH-IGF-SST system is an endocrine system that includes growth hormone (GH), IGF1 and IGF2, associated carrier proteins and receptors, and somatostatin (SST) and plays a key role in controlling the regulation of metabolism and physiologic processes. ...
Serum growth hormone (GH) levels decreased, and GH-responsive IGF1, IGF binding protein 3 (IGFBP3) and acid labile subunit (ALS) increased. There was a significant but limited increase in body weight and length, similar to the response to rhIGF1 treatment in LS patients. All the major ...
Among the tested molecules, E2 had the most pronounced effect, followed by GH, while Tes showed the opposite effect. Conclusion GH/E2 alleviated inflammation in a COVID-19-type proinflammatory model, but Tes showed the opposite effect. Keywords Growth hormone, Sex hormones, COVID-19, ...
First, GHD is associated with a decreased hormone-sensitive lipase (HSL) activity, which has an essential role in the process of lipolysis [118]. Second, GH may influence the expression of CIDE-A (cell-death-inducing DFF45-like effector) pro- tein which has been associated with lipid ...
GH remains attractive to athletes because of its potential for increased skeletal muscle and concomitant loss of fat. Studies in patients with hypopitutiarism and growth hormone deficiency who receive rhGH have repeatedly had a normalization of body composition, with increased lean body mass. This im...
Growth hormone-releasing hormone (GHRH) is a peptide belonging to the secretin/glucagon family of neuroendocrine and gastrointestinal hormones. Human GHRH (hGHRH) peptide comprises 44 amino acid residues. While the best-known site of production of GH-RH is the hypothalamus, various peripheral organs...
“Growth hormone (GH)-independent dimerization of GH receptor by a leucine zipper results in constitutive activation,” J Biol Chem. Jun. 2, 2000;275(22):17000-7. Bell, JA et al. “Crystallization and preliminary x-ray characterization of bovine growth hormone. Purification of bovine ...