Growth hormone (GH) is a key modulator of growth and GH over-secretion can lead to gigantism. One form is X-linked acrogigantism (X-LAG), in which infants develop GH-secreting pituitary tumors over-expressing the orphan G-protein coupled receptor, GPR101. The role of GPR101 in GH secreti...
CKD is a state of growth hormone (GH) insensitivity that is characterized by deficiency of functional insulin-like growth factor 1 (IGF1) due to reduced GH receptor expression in target organs such as the liver and disturbed GH receptor signalling via the Janus kinase 2 (JAK2)– signal ...
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GH remains attractive to athletes because of its potential for increased skeletal muscle and concomitant loss of fat. Studies in patients with hypopitutiarism and growth hormone deficiency who receive rhGH have repeatedly had a normalization of body composition, with increased lean body mass. This im...
feed conversion rate and improve meat quality,which is a new approach of animal growth regulation.GH mediated by IGF-Ⅰ regulates animal growth and cell differentiation.We will discuss the constitution and function of GH/IGF-Ⅰ axis,and mechanism of growth hormone regulation of IGF-Ⅰ expression ...
Interestingly, the activity of GHS is not fully specific for GH release; in fact, they possess also slight prolactin- (PRL-), adrenocorticotropin hormone- (ACTH-) and cortisol-releasing effect, at least after acute administration (2–4,10). Moreover, GHS also haveextra-hormonal acti...
Hormone pathways also converge in the regulation of common targets. Interestingly, however, transcriptomic analysis using GA, IAA, and BRs has suggested that the exogenous applica- tion of each hormone regulates a set of specific target genes independently (Nemhauser et al., 2006). This finding ...
Growth hormone (GH) secretion, either spontaneous or evoked by provocative stimuli, is markedly blunted in obesity. In fact obese patients display, compare... M Scacchi,AI Pincelli,F Cavagnini - 《Int J Obes Relat Metab Disord》 被引量: 615发表: 1999年 Growth hormone in obesity Growth horm...
The GH-IGF-SST system is an endocrine system that includes growth hormone (GH), IGF1 and IGF2, associated carrier proteins and receptors, and somatostatin (SST) and plays a key role in controlling the regulation of metabolism and physiologic processes. ...
Serum growth hormone (GH) levels decreased, and GH-responsive IGF1, IGF binding protein 3 (IGFBP3) and acid labile subunit (ALS) increased. There was a significant but limited increase in body weight and length, similar to the response to rhIGF1 treatment in LS patients. All the major ...