In children with neurofibromatosis type 1 (NF1) and optic pathways glioma (OPG), growth hormone (GH) excess has been rarely reported and mainly associated to central precocious puberty. The aim of our study is to evaluate the prevalence of GH excess, the association with central precocious ...
pituitary gland Growth hormone is secreted by the anterior lobe of the pituitary gland and is vital for normal physical growth in children. (more) growth hormone Ask the Chatbot a Question More Actions Also known as: GH, HGH, STH, human growth hormone, somatotropic hormone, somatotropin...
An excess of growth hormone in children results in gigantism; these children grow to be over 7 ft (213 cm) in height and have disproportionately long limbs. Excess growth hormone produced after puberty has little effect on the growth of the skeleton, but it results in a disease affecting ter...
The growth hormone (GH)–insulin-like growth factor (IGF) axis consists of central neuro-anatomical, regulatory and genetic systems, and the peripheral intracellular GH signalling pathway The introduction of recombinant human GH (rhGH) in 1985 ended the phase of pituitary-derived human growth hormone...
Growth hormone excess in children with neurofibromatosis type-1 and optic glioma. Am J Med Genet A. 2017;173:2353–58. Article CAS Google Scholar Hannah-Shmouni F, Beckers P, Trivellin G, Lyssikatos C, Josefson JL, Lodish M, Stratakis CA. Neurofibromatosis 1 and growth hormone excess. ...
In childhood, there are many possible causes, both genetic and environmental, of short stature and a slow growth rate. Careful laboratory and clinical evaluations, including measurements of IGF-1 levels, are required to determine whether the cause is a deficiency of growth hormone. If present,...
Children and adults with growth hormone deficiency can now be treated with growth hormone supplements. Also, patients suffering from diseases that lead to muscle wasting and weakness (like AIDS) also benefit from such supplements. However, in some cases these supplements are exploited to reverse ...
The prevalence of growth hormone deficiency is still uncertain, but is probably about 1 in 4000 live births. The clinical features of growth hormone deficiency are usually fairly clear, with short stature, low growth velocity, excess subcutaneous fat and delayed skeletal maturation being the ...
whereas those with excess in growth hormone have gigantism or acromegaly. Current therapeutic indications for hGH use include Turner Syndrome and Adult Growth Hormone Deficiency syndrome. Due to its potential for enhanced growth, growth hormone has become attractive to athletes as a potential ergogenic...
CONSENSUS Statement E V I D E N C E -B A S E D G U I D E L I N E Clinical practice recommendations for growth hormone treatment in children with chronic kidney disease Jens Drube1,2, Mandy Wan3, Marjolein Bonthuis4, Elke Wühl5, Justine Bacchetta6, Fernando ...