近日,浙江省肿瘤医院叶足研究员与美国MD安德森癌症中心John A. Tainer教授团队合作,在Nature Communications期刊在线发表了题为GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against...
2024年3月8日,浙江省肿瘤医院叶足研究员与美国MD安德森癌症中心John A. Tainer教授团队合作在Nature Communications期刊在线发表了题为“GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate i...
该基因编码的蛋白与表皮生长因子受体结合,包含一个sh2结构域和两个sh3结构域。它的两个SH3结构域直接与其他蛋白质富含脯氨酸的区域形成复合物,其SH2结构域与酪氨酸磷酸化序列结合该基因与线虫的sem5基因相似,参与信号转导途径。已经发现了两个编码不同亚型的选择性剪接转录变体。[由RefSeq提供,2008年7月] ...
The adaptor protein Grb2 is a critical component of the cell signaling machinery that is deregulated in several pathological processes, including cancer. A plurality of interactions make Grb2 an important cellular hub linking activated cell surface receptors to downstream targets by binding to specific...
Positive IHC detected in human pancreas cancer tissueNote: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0 Positive IF/ICC detected in HEK-293 cells Planning an IHC experiment? We recommend our IHCeasy GRB2 Ready...
(2008). GRB2. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-47648-1_2513 Download citation .RIS .ENW .BIB DOIhttps://doi.org/10.1007/978-3-540-47648-1_2513 Publisher NameSpringer, Berlin, Heidelberg ...
This functional profile makes Grb2 a high priority target for anti-cancer drug development. Knowledge of Grb2 protein structure, its component Src homology domains and their respective structure-function relationships has facilitated the rapid development of sophisticated drug candidates that can penetrate...
- 《British Journal of Cancer》 被引量: 0发表: 2014年 EGFR、IGF-1R、mTOR在子宫颈上皮内瘤变及宫颈癌中的表达及意义 目的探讨表皮生长因子受体(EGFR)、胰岛素样生长因子1受体(IGF-1R)、哺乳动物雷帕霉素靶蛋白(mTOR)在子宫颈上皮内瘤变(CIN)及宫颈癌中表达的意义。方法选取无锡市妇幼... 张卫,印永祥,...
Cancer of the stomach, probably the second most common carcinoma. There are various inherited cancer predisposition syndromes, including hereditary nonpolyposis colon cancer (See GTBP), adenomatous polyposis coli), Peutz-Jeghers syndrome, Cowden disease, and the Li-Fraumeni syndrome. Another form is ...