A substantial proportion of patients with chronic hepatitis B (CHB) do not fall into any of the defined phases and are considered to be in the "gray zone" or "indeterminate phase." Most of the current clinical practice guidelines have no recommendations for antiviral treatment for them. ...
(Nozaki et al., 2003). In contrast, inhibition of hepatitis B virus infection in vitro depends upon the interaction of Lf with hepatocytes rather than the virus (Hara et al., 2002). The lactoferricin region of Lf is partly responsible for its ability to inhibit binding of HIV to theCXCR...
Should Indications for Antiviral Therapy for Hepatitis B Be Broadened to Include Immune-Tolerant Patients, Inactive Carriers, or Patients in the “Gray Zone”? Abstract Purpose of Review Current antiviral therapy effectively suppresses hepatitis B virus (HBV) replication and improves the prognosis. It ...
A high proportion of patients in GZ〣 had advanced fibrosis (33.3%) or cirrhosis (25.8%). Older age, HBeAg positive status and higher ALT levels were independently risk factors of advanced disease in gray zone CHB patients. Therefore, our results revealed that more than a quarter of CHB ...