The E2100 trial demonstrated significantly greater progression-free survival and overall response rates with a bevacizumab plus paclitaxel combination compared with paclitaxel alone as first-line therapy in previously untreated metastatic breast cancer patients. Other studies in heavily pretreated patients have...
The histologic grade (HG) of breast cancer is an established prognostic factor. The grade is usually reported on a scale ranging from 1 to 3, where grade 3 tumours are the most aggressive. However, grade 2 is associated with an intermediate risk of recurrence, and carries limited information...
PROBLEM TO BE SOLVED: To provide a detection agent for readily detecting highly malignant breast cancer; and a therapeutic agent for highly malignant breast cancer. SOLUTION: The detection agent for malignant breast cancer of the present invention comprises an antibody directed against collagen XIV or...
Breast cancer prognostic classification in the molecular era: the role of histological grade Breast cancer is a heterogeneous disease with varied morphological appearances, molecular features, behavior, and response to therapy. Current routine clin......
Histologic Grade Remains a Prognostic Factor for Breast Cancer Regardless of the Number of Positive Lymph Nodes and Tumor Size: A Study of 161 708 Cases of... Histologic Grade Remains a Prognostic Factor for Breast Cancer Regardless of the Number of Positive Lymph Nodes and Tumor Size: A ...
A study of hormone receptor status and grade of breast cancers 1984-1986 and 1996-97 3088 Introduction: There has been a significant improvement in breast cancer survival in the UK in recent decades. Changes in the molecular epidemiology of breast cancers may have contributed to this, but the ...
Moreover, the coexpression network shows a strong association of these six genes promotes cancer specific biological processes and possibly drives cancer from lower to a higher grade. Collectively the identified genes can act as potential biomarkers for breast cancer diagnosis and prognosis....
Here, we present an analysis of the validity of histological grade as a prognostic factor and a consensus view on the significance of histological grade and its role in breast cancer classification and staging systems in this era of emerging clinical use of molecular classifiers....
Breast cancer proteomics reveals a positive correlation between glyoxalase 1 expression and high tumor grade. MA Fonseca-Sánchez,SR Cuevas,G Mendoza-Hernández,... - Spandidos Publications 被引量: 0发表: 2012年 Proteomic Study Reveals That Proteins Involved in Metabolic and Detoxification Pathways Are...
Prognostic stratification of breast cancers remains a challenge to improve clinical decision making. We employ machine learning on breast cancer transcriptomics from multiple studies to link the expression of specific genes to histological grade and clas