a range of inhibitors targeting DDR components have emerged. More importantly, cancers with a high rate of cell division, such as breast cancer, are more responsive to the DDR treatments [10]. Among them, poly-ADP-ribose polymerase (PARP) inhibitors are the most commonly used and related to ...
Cancer incidence escalates exponentially with advancing age; however, the underlying mechanism remains unclear. In this study, we build a chronological molecular clock at single-cell transcription level with a mammary stem cell-enriched population to depict physiological aging dynamics in female mice. We...
(D) Pie chart showing the percentage of Grades I, II, and III breast cancer tissues (n = 191). (E) Percentage of cells expressing NIK in Grade I, II and III tumors. NIK expression levels increase in Grade III tumor (p = 0.07). genes found in the microarray ...
A–G Experimental verification of the biological role of IMMT on cancer cell biology. Representative western blot of IMMT in MDA-MB-231 cells treated with 20 nM negative control siRNA (si-ctrl) and IMMT siRNA (si-IMMT) for 72 h. β-actin serving as loading control (A). Bar chart ...
Our method identifies six disease subtype and one normal clusters. The first split separates the normal samples from the cancer samples. Next, the cancer cluster splits into low grade (pathological grades 1 and 2) and high grade (pathological grades 2 and 3) while the normal cluster is unchan...
(B) Pie chart classifying the type of mutations observed in all genes. Most of the mutations fall under nonsense and synonymous type. Other mutation types, such as frameshift and in-frame mutations, were also observed. Integrated analysis of The Cancer Genome Atlas (56) has demonstrated ...
(E) HE staining to show the distant metastasis potentials of breast cancer cells lines with or without PSAT1 ectopic expression.(F) Statistical chart of metastasis in PSAT1 and vector group of nude mice. (G, H) MDA-MB-231-luc-Scramble and MDA-MB-231-luc-KD cells were injected into ...
There is an inverse relation between the cost of treatment and patient survival as the breast cancer progresses to higher grades. Therefore, screening and diagnosing breast cancers at earlier stages is needed which can improve patient survival. The INhibitor of Growth (ING) family of tumour ...
(d) Immunoprecipitation shows that TRPV4 is both tyrosine phosphorylated and overexpressed in 4T07 and 4T1 breast cancer cells. Bar chart showing the average values (n = 3, ±s.d.) and p values from unpaired Student's t-test are also shown (e) Q-PCR showing increased ...
Breast cancer is the most common malignant disease worldwide, with over 2.26 million new cases in 2020. Its diagnosis is determined by a histological review of breast biopsy specimens, which can be labor-intensive, subjective, and error-prone. Artificial Intelligence (AI)—based tools can support...