Molecular Biological Features of Nottingham Histological Grade 3 Breast CancersIntroductionCancer biology dominates the behavior and prognosis of a tumor. Although Nottingham histological grade is a subjective pathological determination, it has been accepted as a surrogate model for cancer biology. As such,...
breast cancerECMmass spectrometryTN tumorsTumor extracellular matrix (ECM) plays a pivotal role in outcome of breast cancer (BC) patients. Overespression of 58 genes, encoding 43 structural ECM proteins, has been identified to determine a specific cluster of BC with accelerated metastatic potential ...
In early-stage breast cancer, where the use of systemic therapy has to be determined for every patient, the three main prognostic determinants used in routine practice are lymph node (LN) status, tumor size, and histological grade. The Nottingham (Elston-Ellis) modification of the Scarff-Bloom...
A similar matched set of 48 high grade tumors was used to investigate the selectivity of proteins for the low grade luminal A tumor group and to gain potential insight into common versus distinct metastatic processes during progression of low and high grade tumors and of different breast cancer ...
Breast cancer proteomics reveals a positive correlation between glyoxalase 1 expression and high tumor grade. MA Fonseca-Sánchez,SR Cuevas,G Mendoza-Hernández,... - Spandidos Publications 被引量: 0发表: 2012年 Proteomics of curcurbit phloem exudate reveals a network of defence proteins Many ...
Methods. We identified 123,780 cases of stages 1–3 primary female invasive breast cancer from California Cancer Registry. The surrogate classification was derived using ER/PR/HER2 and tumor grade. Kaplan-Meier survival analysis and Cox proportional hazards modeling were used to assess differences in...
In grade 3, the cells are poorly differentiated and tend to grow faster than cells of other grades [[6], [7], [8]]. In general, a lower grade number indicates slower-growing cancer that is less likely to spread with better prognosis, while higher-grade breast cancer may grow and ...
(grade 1) that demonstrates high homology to the normal breast terminal duct lobular unit, tubule formation (>75%), a mild degree of nuclear pleomorphism, and low mitotic count.(b)A moderately differentiated tumor (grade 2).(c)A poorly differentiated (grade 3) tumor with a marked degree ...
The prognosis of invasive breast cancer is strongly determined by tumour size (T), nodal spread (N) and distant metastases (M) at the time of diagnosis [1,2,3,4]. In addition, routine immunohistochemistry (IHC) tumour markers, i.e. estrogen receptor (ER), progesterone receptor (PR) and...
Two of the most predictive measures of breast cancer (BC) patient mortality are tumor progression and immune infiltration [1,2,3]. By decoding and recognizing the underlying molecular patterns of invasive breast tumors, clinicians may provide high-grade tumor patients with appropriate prognosis and ...