Most cisplatin-resistant cancer cells are associated with increased GSH synthesis11,12 and formation of GSH-cisplatin conjugates mediated by glutathione S-transferase P1 (GSTP1) is responsible for cisplatin inactivation5. The majority of cisplatin-induced DNA lesions are removed through homologous ...
This protein family also includes FXYD1 (Phospholemman), FXYD2 (ATP1G1), FXYD3 (MAT8), FXYD4 (CHIF), FXYD6 and FXYD7 (RIK).6 FXYD5 is able to modulate cellular junctions, to influence chemokine production, and to affect cell adhesion.7,8 To the best of our knowledge, this is ...