Fluids and Barriers of the CNS volume 21, Article number: 62 (2024) Cite this article 967 Accesses Metrics details Abstract Background Pharmacotherapy for brain diseases is severely compromised by the blood-brain barrier (BBB). ABCB1 and ABCG2 are drug transporters that restrict drug entry into...
(IBA, LifeSciences) for 1.5 h by rotation. After incubation, the resin was collected and washed with 20 column volumes of wash buffer containing 50 mM MOPS (pH 7.0), 100 mM KCl, 10% glycerin, 5 mM MgCl2, 1 mM DTT, 0.05% (wt/vol) DDM, 0.01% (wt/vol) CHS, 1 mM...
Zn(NO3)2 and Cu(NO3)2 were analytical grade products. The concentrations of metal ion stock solutions were determined by atomic absorption spectroscopy. The synthesis and characterization of probes A (C343-GDD-OH)31 and B (Ac-WD-OH)40 have been reported previously. HPNPP was prepared as ...
High-performance liquid chromatography (HPLC)-grade LVFX powder (Sigma-Aldrich Japan, Tokyo, Japan) was dissolved and diluted with a cation-adjusted Mueller Hinton broth supplemented with 1% horse defibrinated blood (Nikken Bio., Kyoto, Japan) to obtain 10 µg/mL, 20 µg/mL or 40...
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(v/v) for 5 h followed by pure medium-grade acrylic LR White resin (Agar Scientific,http://www.agarscientific.com) for 2 days, taking care to replace the resin every day. Samples were finally placed in the center of capsules and placed in a heat chamber for 24 h (67 °C). ...