While these pathways are compelling targets for treatment given known genetic aberrations in both pathways in pHGG2,5, both compounds are known substrates of ATP-dependent efflux pumps P-gp and BCRP, limiting their brain exposure34,35. Therefore, we selected paxalisib (GDC0084) and mirdametinib...
11 The gene expression data were deposited in NCBI’s Gene Expression Omnibus12 and are accessible through GEO Series accession number GSE131978 (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE131978). Reverse transcription and real-time quantitative PCR (RT-qPCR) One microgram of ...
GEO, gene expression omnibus; GIC, glioma initiating cell; GS, gliosarcoma; GSAV, gene set variation analysis; HADS, hospital anxiety and depression scale; HGG, high-grade glioma; 1H-MRS, hydrogen proton MRS; IAUC, initial area under the enhancement curve; IDH, isocitrate dehydrogenase; IDIP...