While these pathways are compelling targets for treatment given known genetic aberrations in both pathways in pHGG2,5, both compounds are known substrates of ATP-dependent efflux pumps P-gp and BCRP, limiting their brain exposure34,35. Therefore, we selected paxalisib (GDC0084) and mirdametinib...
ABCG2: ATP-binding cassette subfamily B member 2; ADC, apparent diffusion coefficient; aDMG, adult diffuse midline glioma; advMRI, advanced MRI; AI, artificial intelligence; 5-ALA, 5-aminolevulinic acid; ANN, artificial neural network; APT, amide proton transfer; APTw, amide proton transfer ...