While these pathways are compelling targets for treatment given known genetic aberrations in both pathways in pHGG2,5, both compounds are known substrates of ATP-dependent efflux pumps P-gp and BCRP, limiting their brain exposure34,35. Therefore, we selected paxalisib (GDC0084) and mirdametinib...
'The correlation between protein molecular weight and the number of lysine or basic amino acid residues was found to be high for broad range molecular weight standards, subunits of Escherichia coli F1F0-ATP synthase and the translated open reading frame of E. coli. A relatively poor correlation ...
'The correlation between protein molecular weight and the number of lysine or basic amino acid residues was found to be high for broad range molecular weight standards, subunits of Escherichia coli F1F0-ATP synthase and the translated open reading frame of E. coli. A relatively poor correlation ...
ABCG2: ATP-binding cassette subfamily B member 2; ADC, apparent diffusion coefficient; aDMG, adult diffuse midline glioma; advMRI, advanced MRI; AI, artificial intelligence; 5-ALA, 5-aminolevulinic acid; ANN, artificial neural network; APT, amide proton transfer; APTw, amide proton transfer ...