答:Gr-1单抗通常认为是粒细胞标记,但实际上,它既可结合Ly-6G也可结合Ly-6C。大多数 Gr1+ CD11b- 细胞是 Ly6C+ LyG-,Ly6C可表达在浆细胞、部分粒细胞和T 细胞(包括记忆 T 细胞)表达。所以Gr1+ CD11b-细胞可能CD8是阳性的,如果补做CD8是阳性的...
Here, we describe a unique type of APC, Gr1−/lowCD11b−/low cells with a granularity and size characteristic of myeloid cells and with the ability to present Ag for crosspresentation. These cells constitutively express MHCII and the costimulatory molecules, CD80, CD86, and CD40. They do...
cells to the lung in an attempt to wall off bacilli by forming a granuloma. Gr1(int)CD11b(+) cells are called myeloid-derived suppressor cells (MDSC) and play a major role in regulation of inflammation in many pathological conditions. Although MDSC have been described primarily in cancer ...
Gr-1(+) cells could be found on the edges of necrotic lung lesions in NOS2-/-, RAG-/-, and C3HeB/FeJ, but were absent in wild-type mice. Both populations of Gr1(+)CD11b(+) cells expressed high levels of arginase-1, and IL-17, additional markers of myeloid derived suppressor ...
CD11b+ Gr1dim cells were transferred to ZyA-treated SKG mice.MDSCs, Th17 cells, and group 1 and 3 innate lymphoid cells (ILC1s and ILC3s) were increased in the lungs; the proportion of these cells varied with ILD severity. In this process, we found that a unique cell population, CD...
采用小鼠4T1乳腺癌模型观察MSC通过CD11b+Gr1+细胞对肿瘤生长的影响.结果 MSC能够促进骨髓中CD11b+Gr1+细胞的存活和生成,同时可诱导正常小鼠骨髓中CD11b+Gr1+细胞对T细胞的抑制作用.动物实验结果显示,MSC处理后的骨髓CD11b+Gr1+细胞可以促进肿瘤的生长,加速小鼠的死亡.结论 MSC可以通过促进骨髓来源的CD11b+Gr1+细...
EasySep™小鼠MDSC(CD11b+Gr1+)分选试剂盒是一款阴性选择试剂盒,在短短18分钟内即可从幼稚或荷瘤小鼠的骨髓、外周血或脾脏中富集CD11b + Gr1 +细胞。分离细胞可立即用于下游应用,如流式细胞术、细胞分类和细胞培养。 优点: - 快速、简便、无柱; - 细胞未被标记;...
肿瘤微环境中F480CD11bGr1单核细胞活化机制的研究 华中科技大学 博士学位论文 肿瘤微环境中F4/80+CD11b+Gr-1+单核细胞活化机制的研究 姓名:*** 申请学位级别:博士 专业:生物化学与分子生物学 指导教师:**化 2010-05华中科技大学同济医学院博士研究生学位论文 +++ 肿瘤微环境中F4/80CD11bGr-1 单核细胞活化...
CD11b(+) Gr1(+) bone marrow cells ameliorate liver fibrosis by producing interleukin-10 in mice. Hepatology 56, 1902-1912 (2012).Suh YG, Kim JK, Byun JS, Yi HS, Lee YS, Eun HS, et al. CD11b+ Gr1+ bone marrow cells ... GS Yang,JK Kim,SB Jin,... - 《Hepatology Official Jou...
Our recent work has described the ability of LPS to increase the frequency of CD11b+Gr1intF4/80+ cells in the lung tissue of mice in a dose-dependent fashion that is dependent on TLR4 and MyD88. Although the Gr1int cells are readily detectable in the lung tissue of LPS-treated mice, ...