[4] Zhang B, Xue L, Wu Z B. Structure and function of somatostatin and its receptors in endocrinology. Endocr Rev, 2025, 46(1): 26-42 [5] Lee J, Gonzalez-Hernandez A J, Kristt M, et al. Distinct beta-arrestin c
GPCR structure and function relationship: identification of a biased apelin receptor mutantapelin receptorG protein-coupled receptorsmolecular dynamicspharmacologysignaling biasBiased ligands of G protein-coupled receptors (GPCRs) may have improved therapeutic benefits and safety profiles. However, the ...
Fig4. Detection of human GLP-1R expression in HO hGLP-1R knockin mice by IHC.Pancreas, salivary gland, colon, heart, lung, brian, stomach and duodenum were collected from homozygous hGLP-1R mice (HO/HO), and analyzed by IHC with anti-human GLP-1R antibody. Human GLP-1R is specifically...
GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1-2 September 2014. Naunyn Schmiedebergs Arch Pharmacol. 2015; 388: 883-903.Heifetz A, Schertler GF, Seifert R, Tate CG, Sexton PM, Gurevich VV...
5. Yang, D., et al., G protein-coupled receptors: structure-and function-based drug discovery. Signal transduction and targeted therapy, 2021. 6(1): p. 7. 6. Buck, A.K., et al., CXCR4-targeted theranostics in oncology. Eur J Nucl Med Mol Imaging, 2022. 49(12): p. 4133-4144...
[5] Yang D, Zhou Q, Labroska V, et al. G protein-coupled receptors: structure- and function-based drug discovery. Signal Transduct Target Ther. 2021;6(1):7. Published 2021 Jan 8. doi:10.1038/s41392-020-00435-w 关于我们 上海南方模式生物科技股份有限公司(Shanghai Model Organisms Center,...
et al. G protein-coupled receptors: structure- and function-based drug discovery. Sig Transduct Target Ther 6, 7 (2021). https://doi.org/10.1038/s41392-020-00435-w [5].https://www.fda.gov [6].Zhang, R., Xie, X. Tools for GPCR drug discovery. Acta Pharmacol Sin 33, 372–384 ...
Crystal structure of the β2 adrenergic receptor–Gs protein complex. Nature 477, 549–555 (2011). Article CAS PubMed PubMed Central ADS Google Scholar Rosenbaum, D. M. et al. GPCR engineering yields high-resolution structural insights into β2-adrenergic receptor function. Science 318, 1266...
The GPCR Network was established in 2010 with the aim of structurally characterizing 15–25 representative human G protein-coupled receptors (GPCRs) within 5 years; so far, more than eight have been determined. Here, Stevens and colleagues provide an ove
[5] Yang D, Zhou Q, Labroska V, et al. G protein-coupled receptors: structure- and function-based drug discovery. Signal Transduct Target Ther. 2021;6(1):7. Published 2021 Jan 8. doi:10.1038/s41392-020-00435-w 关于我们 上海南方模式生物科技股份有限公司(Shanghai Model Organisms Center,...