This chapter explains the structure and function of G-protein-coupled receptors and describes the experimental results from studies conducted on recent crystal structures. Recent reports of crystal structures of
Crystal structure of the β2 adrenergic receptor–Gs protein complex. Nature 477, 549–555 (2011). Article CAS PubMed PubMed Central ADS Google Scholar Rosenbaum, D. M. et al. GPCR engineering yields high-resolution structural insights into β2-adrenergic receptor function. Science 318, 1266...
β-Arrestins (βarrs) are multifunctional intracellular proteins with an ability to directly interact with a large number of cellular partners including the G protein-coupled receptors (GPCRs). βarrs contribute to multiple aspects of GPCR signaling, trafficking and downregulation. Considering the ...
Ligand recognition and G protein coupling of the human itch receptor MRGPRX1 Article Open access 17 August 2023 Structure, function and pharmacology of human itch GPCRs Article 17 November 2021 Subnanomolar MAS-related G protein-coupled receptor-X2/B2 antagonists with efficacy in human mast ...
Structure Therapeutic(硕迪生物,以下简称Structure)就是其中一家,该公司专注于G蛋白偶联受体(GPCR)靶向疗法,目前正处于项目临床验证阶段。2023年2月2日,Structure在纳斯达克上市,股票代码为“GPCR”。截至5月12日16:00,其总市值10.1亿美元。 打...
Biophysics Structure prediction of class A GPCRs THE SCRIPPS RESEARCH INSTITUTE MichinoMayakoStructural models of G-protein-coupled receptors (GPCRs) are valuable in providing insights into the structure-function relationship, and for their potential application in structure-based drug discovery. The ...
Glazer, Y. Marantz, S. Bar-Haim, S. Noiman, Z. Naor, and O. M. Becker. 2001. Modeling the 3D structure of GPCRs from sequence. Med. Res. Rev. 21:472-483.Shacham S, Topf M, Avisar N, Glaser F, Marantz Y, Bar-Haim S, Noiman S et al. Modeling the 3D structure of GPCR...
慢性病生物制药公司Structure Therapeutics(GPCR.US)申请在美上市 拟筹集1亿美元 智通财经APP获悉，生物制药公司Structure Therapeutics周四向美国证券交易委员会(SEC)提交了首次公开募股(IPO)申请，拟筹资最高达1亿美元。该公司计划在纳斯达克上市，股票代码为“GPCR”。资料显示，Structure Therapeutics致力于开发和提供新型...
Structure, function and pharmacology of human itch GPCRs G蛋白偶联受体兴奋剂受体敌手肥大细胞内源性激动剂药理学内生细胞生物学化学生物生物化学免疫学多巴胺受体D1 作者 Can Cao,Hye Jin Kang,Isha Singh,He Chen,Chengwei Zhang,Wenlei Ye,Byron W. Hayes,Jing Liu,Ryan H. Gumpper,Brian J. Bender,Samuel...
Type 2 bradykinin receptor (B2R) is an essential G protein-coupled receptor (GPCR) that regulates the cardiovascular system as a vasodepressor. Dysfunction of B2R is also closely related to cancers and hereditary angioedema (HAE). Although several B2R ag