SRF Elk-1 C-Jun C-Fos STATs NF-KB NFAT GP C R GTP GTP GTP GTP GTP GDP PYK2 Paxillin P P P BCL10 BIMP1 SRF Elk-1 c-Jun c-Fos STATs NFAT Gene Expression GPCR Pathway GP C R GP C R GP C R GP C R GP C R Ga 12/13 LARG Rho ROCK SRF Rap1 BRaf PKA EPAC cAMP MEKs ...
Here, we show that the mitogen-activated protein kinase (MAPK) pathway and its upstream and downstream actors underlie the fitness trade-offs associated with insecticide resistance in the whitefly Bemisia tabaci. Specifically, we find a key cytochrome P450 gene CYP6CM1, that confers neonicotinoids ...
14.Carmon, K.S., et al., Carmon, K.S., et al.,LGR5 receptor promotes cell–cell adhesion in stem cells and colon cancer cells via the IQGAP1–Rac1 pathway.Journal of Biological Chemistry, 2017.292(36): p. 14989-15001. 15.Gong, X., et al., Gong, X., et al.,LGR5-Targeted...
Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2. Mol Cell 54, 119-132, doi:10.1016/j.molcel.2014.02.020 (2014). 4 Rao, F. et al. Inositol pyrophosphates promote tumor growth and metastasis by antagonizing liver kinase ...
(OMP-18R5; anti-Frizzled) targeting the WNT pathway in a phase I study for patients with advanced solid tumors. J. Clin. Oncol. 2013, 31, 2540.6.Li, C.; Yang, M.; Wang, X.; Zhang, H.; Yao, C.; Sun, S.; Liu, Q.; Pan, H.; Liu, S.; Huan, Y.; et al. Glutazumab...
(Fig.2d–e). We measured cAMP levels in HEK cells transfected with DREADD-GPR65 and found a significant increase after CNO stimulation, which was not detected in empty vector-transfected cells (Fig.7c). Stimulation of DREADD-GPR65 also impacted the MAPK pathway and reduced SRE-mediated ...
5.Smith, D.C.; Rosen, L.S.; Chugh, R.; Goldman, J.W.; Xu, L.; Kapoun, A.; Brachmann, R.K.; Dupont, J.; Stagg, R.J.; Tolcher, A.W.; et al. First-in-human evaluation of the human monoclonal antibody vantictumab (OMP-18R5; ...
[3] SchinkeC, Giricz O, Li W, et al.IL8-CXCR2 pathway inhibition as a therapeutic strategy against MDS and AML stem cells. Blood. 2015; 125(20): 3144-52; [4] Zhang Q, Xu F, Shi Y, et al. C-X-C motif chemokine receptor 4 promotes tumor angiogenesis in gastric cancer via act...
[4]Galaz-Montoya M, Wright S J, Rodriguez G J, et al. β2-Adrenergic receptor activation mobilizes intracellular calcium via a non-canonical cAMP-independent signaling pathway[J]. Journal of Biological Chemistry, 2017, 292(24): 9967-9974. ...
[4]Galaz-Montoya M, Wright S J, Rodriguez G J, et al. β2-Adrenergic receptor activation mobilizes intracellular calcium via a non-canonical cAMP-independent signaling pathway[J]. Journal of Biological Chemistry, 2017, 292(24): 9967-9974. ...