演讲嘉宾将简要回顾TJM2抗体开发过程并分享TJM2开发的经验。 Webinar Title:GM-CSF antibody as the potential treatment for cytokine release syndrome (CRS) associated with COVID-19 Abstract: TJM2 monoclonal antibody is a GM-C...
Problem to be solved: to provide a pharmaceutical composition for treating inflammatory diseases selected from the group including rheumatoid arthritis, SLE, psoriatic arthritis, ankylosing spondylitis, juvenile idiopathic arthritis, osteoarthritis and sarcoidosis.A composition comprising a neutralizing antibody ...
The MP1-22E9 antibody is a neutralizing antibody. Mouse GM-CSF is a 14 kDa factor produced mainly by activated T cells and macrophages. Other cell types, such as endothelium and fibroblasts, also secrete GM-CSF in response to TNF-alpha, IL-2, IL-1, and IFN-gamma. GM-CSF stimulates ...
Rationale for neutralizing GM-CSF in COVID-19 Anti-inflammatory therapies have attracted great interest in COVID-19, and an immunomodulatory agent that is able to prevent or reduce the disease-driving hyperactive immune response could be a beneficial therapy for late-stage COVID-19 (ref.25). I...
Figure 7. Inhibition of hGM-CSF-induced Reporter Activity by hGM-CSF Neutralizing Antibody in hGM-CSF Effector Reporter Cells (Clone 10).药物靶点模型 报告基因细胞模型可以很好的反映分子作用机制,同时具备更小的变异性和更好的可操作性,已被中检院及药企广泛应用于抗体药物生物活性的检定,对于药物研发、...
When tested for their capacity to neutralize GM-CSF bioactivity on TF-1 cells, the IgG fraction isolated from serum of healthy donors did not show detectable neutralizing activity. However, when serum IgG was supplemented with a single non-neutralizing monoclonal antibody, a clear neutralizing ...
S1E) were incubated with a neutralizing antibody against bFGF or GM-CSF in the lower chamber of the transwells, the migration of the breast cancer cells was greatly reduced as compared to when senescent cells were incubated with an anti-β-actin antibody or when left untreated (Fig. 3A-B)...
The MP1-22E9 antibody is a neutralizing antibody. Mouse GM-CSF is a 14 kDa factor produced mainly by activated T cells and macrophages. Other cell types, such as endothelium and fibroblasts, also secrete GM-CSF in response to TNF alpha, IL-2, IL-1, and IFN gamma. GM-CSF stimulates ...
TJM2 is an internally discovered neutralizing antibody against human GM-CSF, an important cytokine that plays a critical role in chronic inflammation and destruction in autoimmune diseases such as RA. GM-CSF can polarize mac...
Molecular basis of in vitro affinity maturation and functional evolution of a neutralizing anti-human GM-CSF antibody. MAbs. 2016;8(1):176–86. https://doi.org/10.1080/19420862.2015.1099774. Article CAS PubMed Google Scholar Finkelman FD, Madden KB, Morris SC, Holmes JM, Katona IM, ...