演讲嘉宾将简要回顾TJM2抗体开发过程并分享TJM2开发的经验。 Webinar Title:GM-CSF antibody as the potential treatment for cytokine release syndrome (CRS) associated with COVID-19 Abstract: TJM2 monoclonal antibody is a GM-C...
演讲嘉宾将简要回顾TJM2抗体开发过程并分享TJM2开发的经验。 Webinar Title:GM-CSF antibody as the potential treatment for cytokine release syndrome (CRS) associated with COVID-19 Abstract: TJM2 monoclonal antibody is a GM-CSF neutralizing antibody (humanized immunoglobulin IgG1), developed by I-Mab, ...
Figure 6. Dose Response of Recombinant Human GM-CSF in hGM-CSF Effector Reporter Cells (Clone 10). Figure 7. Inhibition of hGM-CSF-induced Reporter Activity by hGM-CSF Neutralizing Antibody in hGM-CSF Effector Reporter Cells (Clone 10). 药物靶点模型 报告基因细胞模型可以很好的反映分子作用机制,...
FIELD: medicine.;SUBSTANCE: invention relates to medicine and concerns use of a neutralizing antibody or its functional fragment specifically binding to primate GM-CSF, for treating an inflammatory disease selected from a group consisting of rheumatoid arthritis, SLE, psoriatic arthritis, ankylosing ...
Figure 7. Inhibition of hGM-CSF-induced Reporter Activity by hGM-CSF Neutralizing Antibody in hGM-CSF Effector Reporter Cells (Clone 10).药物靶点模型 报告基因细胞模型可以很好的反映分子作用机制,同时具备更小的变异性和更好的可操作性,已被中检院及药企广泛应用于抗体药物生物活性的检定,对于药物研发、...
Description: The MP1-22E9 antibody reacts with mouse granulocyte/macrophage - colony stimulating factor (GM-CSF). The MP1-22E9 antibody is a neutralizing antibody. Mouse GM-CSF is a 14 kDa factor produced mainly by activated T cells and macrophages. Other cell types, such as endothelium and...
Description: The MP1-22E9 antibody reacts with mouse granulocyte/macrophage - colony stimulating factor (GM-CSF). The MP1-22E9 antibody is a neutralizing antibody. Mouse GM-CSF is a 14 kDa factor produced mainly by activated T cells and macrophages. Other cell types, such as endotheliu...
Description: The MP1-22E9 antibody reacts with mouse granulocyte/macrophage - colony stimulating factor (GM-CSF). The MP1-22E9 antibody is a neutralizing antibody. Mouse GM-CSF is a 14 kDa factor produced mainly by activated T cells and macrophages. Other cell types, such as endothelium and...
The presence of ILC3s (Figure 5A) or ILC3-conditioned media (Figure S5A) enhanced macrophage IL-1β and MHC-II expression, and suppressed IL-10, effects that were inhibited by the addition of a GM-CSF-neutralizing antibody. Similarly, ILC3-conditioned media increased Tnfsf15 (encoding TL...
et al. Neutralizing granulocyte/macrophage colony-stimulating factor inhibits cigarette smoke-induced lung inflammation. Am. J. Respir. Crit. Care Med. 182, 34–40 (2010). Article CAS PubMed Google Scholar Botelho, F. M. et al. A mouse GM-CSF receptor antibody attenuates neutrophilia in mic...