Webinar Title:GM-CSF antibody as the potential treatment for cytokine release syndrome (CRS) associated with COVID-19 Abstract: TJM2 monoclonal antibody is a GM-CSF neutralizing antibody (humanized immunoglobulin IgG1), de...
Description: The MP1-22E9 antibody reacts with mouse granulocyte/macrophage - colony stimulating factor (GM-CSF). The MP1-22E9 antibody is a neutralizing antibody. Mouse GM-CSF is a 14 kDa factor produced mainly by activated T cells and macrophages. Other cell types, such as endothelium and...
GM-CSFantibody productionneutralisationclinical effectsThere is a high risk of developing neutralizing and non-neutralizing antibodies when GM-CSF is used as an immunomodulatory agent in non-immune compromised patients and not in combination with chemotherapy. The presence of neutralizing antibodies may ...
hGM-CSF Effector Reporter Cell CBP74149 Figure 6. Dose Response of Recombinant Human GM-CSF in hGM-CSF Effector Reporter Cells (Clone 10). Figure 7. Inhibition of hGM-CSF-induced Reporter Activity by hGM-CSF Neutralizing Antibody in hGM-CSF Effector Reporter Cells (Clone 10). 药物靶点模型 报...
S1E) were incubated with a neutralizing antibody against bFGF or GM-CSF in the lower chamber of the transwells, the migration of the breast cancer cells was greatly reduced as compared to when senescent cells were incubated with an anti-β-actin antibody or when left untreated (Fig. 3A-B)...
et al. Neutralizing granulocyte/macrophage colony-stimulating factor inhibits cigarette smoke-induced lung inflammation. Am. J. Respir. Crit. Care Med. 182, 34–40 (2010). Article CAS PubMed Google Scholar Botelho, F. M. et al. A mouse GM-CSF receptor antibody attenuates neutrophilia in mic...
Rationale for neutralizing GM-CSF in COVID-19 Anti-inflammatory therapies have attracted great interest in COVID-19, and an immunomodulatory agent that is able to prevent or reduce the disease-driving hyperactive immune response could be a beneficial therapy for late-stage COVID-19 (ref.25). ...
Rationale for neutralizing GM-CSF in COVID-19 Anti-inflammatory therapies have attracted great interest in COVID-19, and an immunomodulatory agent that is able to prevent or reduce the disease-driving hyperactive immune response could be a beneficial therapy for late-stage COVID-19 (ref.25). ...
Anti-GM-CSF neutralizing antibodyBiolegend #502319 (clone #BVD2-21C11) ONE-Step™ Luciferase Assay SystemBPS Bioscience #60690 White, clear-bottom 96-well tissue culture plateCorning #3610 Luminometer UniProt # P42229 Mycoplasma Testing
Figure 7. Inhibition of hGM-CSF-induced Reporter Activity by hGM-CSF Neutralizing Antibody in hGM-CSF Effector Reporter Cells (Clone 10).药物靶点模型 报告基因细胞模型可以很好的反映分子作用机制,同时具备更小的变异性和更好的可操作性,已被中检院及药企广泛应用于抗体药物生物活性的检定,对于药物研发、...