我们于 1998年 5月采用抗人胸腺细胞球蛋白 (ATG),环孢霉素A(CsA)和长疗程 (90d)粒 巨噬细胞集落刺激因子(GM CSF)治疗重型再生障碍性贫血 (SAA) 1例获得缓解 ,报道如下. 患者 ,男性 ,39岁.因牙龈出血 1个月 ,面色苍白,乏力半个月于 1997年 5月 2 3日入院.外周血象 :Hb 5 0g/L ,WBC1.9× 10...
Here, we show the HSC gene expression program is biased toward myelopoiesis and differentiation skewed toward granulocyte-monocyte progenitors (GMP) during joint and intestinal inflammation in experimental spondyloarthritis (SpA). GM-CSF-receptor is increased on HSCs and multipotent progenitors, favoring a...
G-CSF对辐射诱导的造血干细胞损伤的影响及其机制 目的亚致死剂量的电离辐射不仅引起急性骨髓损伤,也会导致长期骨髓抑制.造血干细胞衰老是长期骨髓抑制的重要细胞学机制.粒细胞集落刺激因子(G-CSF)可以促进HSC及粒系前... 李程程,李德冠,路璐,... - 《中国药理学与毒理学杂志》 被引量: 0发表: 2016年 ...
Successful administration of intensive care of patients experiencing acute radiation sickness (ARS; also called acute radiation syndrome) is dependent upon the ability to stimulate the recovery of surviving hematopoietic stem cells (HSC), assuming the non-hematopoietic injuries are also survivable with ...
GM-CSF can act on bone marrow to increase the generation of hematopoietic precursor cells, particularly inflammatory leukocytes, from the most immature precursors (Fig. 17-43). As we saw in Chapter 3, CMPs cultured in vitro with GM-CSF give rise to CFU-GEMM cells, which are the progenitors...
G-CSF, granulocyte colony stimulating factor; M-CSF, macrophage colony stimulating factor. (b) Progenitors characterized phenotypically: HSC, hematopoietic stem cell; MPP, multipotent progenitor; LMPP, lymphoid-primed multipotent progenitor; CMP, common myeloid progenitor; CLP, common lymphoid progenitor;...
Lenzilumab 以 GM-CSF 为靶点,作为一种潜在药物正在开发中,可使 CAR-T 疗法更安全、更有效,同时也可用于治疗罕见的血液系统癌症,例如慢性粒单核细胞白血病 (CMML) 和幼年粒单核细胞白血病 (JMML) ).iCell 基因疗法 CAR 工程细胞表达单链可变片段 (ScFvs),其靶向 T 细胞恶性肿瘤的独特表面标记。iCell 在该...
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目的研究GM-CSF诱导人脐血CD34+造血干细胞上CXCR3的表达.方法采用流式细胞仪,实时定量逆转录PCR(RT-PCR)分析,及其配体γIP-10和Mig诱导的趋化和粘附作用分析.结果 CXCR3也表达在受GM-CSF刺激后的CD34+造血干细胞上,但它在新鲜分离的CD34+造血干细胞上不表达.应用实时定量逆转录PCR技术检测新鲜分离的CD34+造血干...
Harmonic CSF-25-100-2UH-LW KANT 801-200-221 压力传感器 turck C12-A21X/AC220V Model update : A.52.8.230.0040 Rexroth PRESS RELIEF VALVE/DBDS 25 G1X/25/2R900433929/Rexroth Micro-EpsilonMesstechnikGmbH&Co.KGWDS-1500-P60-SR-I编码器编码器Micro-EpsilonMesstechnikGmbH&Co.KG ABB3ASC25H203控制板...