The expression of GM-CSF gene was detected by real-time fluorescence quantitative polymerase chain reaction (qRT-PCR). The tail bleeding time of 24h mice was recorded. The levels of plasma prothrombin time (PT), activated partial thromboplastin time (APTT),...
GM-CSF 是一种糖蛋白,主要由 T 淋巴细胞和巨噬细胞分泌,能诱导粒细胞和巨噬细胞集落形成,当机体受到感染时 GM-CSF 将通过不同信号通路促进炎性反应或免疫应答,使受到感染的局部组织发生损伤[6]。仲华等[7]研究发现,急性髓系白血病患者 GM-CSF 水平高于健康对照组,且表明 GM-CSF 与急性髓系白血病患者病情进展...
关键字: CSF2;GMCSF;Sargramostim;粒细胞巨噬细胞集落刺激因子(GM-CSF; 公司简介 上海博尔森生物科技有限公司成立于2020年09月02日,注册地位于上海市松江区石湖荡镇石湖新路95号。上海博尔森生物科技有限公司虽然年轻,但朝气蓬勃,志向远大; 更是一家专注于生命科学与生物技术领域,集产品研发、生产、销售为一体的高...
Granulocyte/Macrophage Colony-Stimulating Factor, CSF-2, MGI-1GM, Pluripoietin-α Accession P48749 GeneID 403923 Source E.coli-derived Canine GM-CSF protein,Ala18-Glu144. Molecular Weight Approximately 14.5 kDa. AA Sequence APTRSPTLVT RPSQHVDAIQ EALSLLNNSN DVTAVMNKAV KVVSEVFDPE GPTCLET...
GVAX is a GM-CSF gene-transduced tumor vaccine. Expression of the GM-CSF gene within either autologous or allogeneic tumor cell populations has demonstrated evidence of immune stimulation in patients and evidence of antitumor activity particularly in prostate cancer and non-small-cell lung cancer. Re...
colony stimulating factor 2 , CSF , GMCSF 细胞定位 Secreted 功能与背景 The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has...
方法PCR扩增人GM-CSF基因编码序列,定向克隆入融合蛋白原核表达载体PET32a+获得重组表达质粒,转化大肠杆菌后用IPTG进行诱导表达,PCR和Western-blot鉴定表达产物。结果 重组质粒经PCR、限制性内切酶及DNA测序证实构建成功;且诱导后能在大肠杆菌中稳定表达PET-GMCSF嵌合蛋白。结论 成功构建并表达了PET-GMCSF蛋白,为进一步研究...
GM—CSF基因瘤苗,初步探讨其作为瘤苗的有效性,并由此探索白 血病免疫治疗的可行性。主要研究结果如下: 1.真核表达重组质粒pcDNA3一GM—csF的构建 用PCR方法从PET.30a(+)一GM.CSF原核表达重组质粒扩增 目的cDNA序列,并引入BamHI和EcoRI酶切位点。用BamH ...
CSF2 (GM-CSF) cloned gene : ORF from ATG to Stop, in pUNO1 expression plasmid selectable in E.coli and mammalian cells. Fully sequenced.
△110一GM—CSFwassuccessfullyrescuedbytransfectionoftheviralgenomicRNAsintoBHK一21cellsandpassagedonMarc一145 cellswhichshownobviouslycytopathicefects.Inaddition,theGM—CSFgeneinsertionandexpressioninrescuedrHN4一 △110-GM-CSFweredetectedbyRT—PCR.DNAsequencingandimmunofluorescenceassay.Itwasalsodemonstratedthatthe ...