CSF超家族有3个重要成员，包括粒细胞-巨 噬 细 胞 集 落 刺 激 因 子 （ granulocyte macrophage-colony stimulating factor ，GM-CSF/CSF2）、巨噬细胞集落刺激因子（macrophage-colony stimulating factor，M-CSF/CSF1）和粒细胞集落刺激因子（granulocyte colony-stimulating factor，G-CSF/CSF3）。与...
CSF超家族有3个重要成员,包括粒细胞-巨 噬细胞集落刺激因子 ( granulocyte macrophage-colony stimulating factor ,GM-CSF/CSF2)、巨噬细胞集落刺激因子(macrophage-colony stimulating factor,M-CSF/CSF1)和粒细胞集落刺激因子(granulocyte colony-stimul
IL-3和GM-CSF基因在基因组中紧密相连,并位于细胞因子基因簇内。这两个基因在转录水平上的高诱导表达已被报道。GM-CSF表达可被IL-10、IFNg和IL-4抑制。 GM-CSF的生物活性通过与表达于单核细胞、巨噬细胞、粒细胞、淋巴细胞、内皮细胞和肺...
巨噬细胞集落刺激因子(M-CSF)又称集落刺激因子1(CSF1)，是一种分泌型细胞因子，可使造血干细胞分化为巨噬细胞或其他相关细胞类型。M-CSF的作用不仅限于单核/巨噬细胞系。通过与其膜受体（CSF1R，又称M-CSF-R）相互作用，M-CSF还可调节早期造血祖细胞的增殖，并影响参与免疫学、代谢、生育力和妊娠的许多生理...
Human GM-CSF, CSF1 and THPO proteins were confirmed to be expressed by ELISA in B-NDG MGMT3 mice. Human CD34+ HSCs (3E4) were intravenously engrafted into wild-type B-NDG mice and homozygous B-NDG MGMT3 male and female newborn mice via the temporal vein. B-NDG mice were treated ...
HumanM-CSF/CSF1HEK293 Cells> 95 %ActiveHis 51112-MNAH 11 Citations MouseM-CSF/CSF1HEK293 Cells> 95 %ActiveNative 10015-H01H 4 Citations HumanGM-CSF/CSF2HEK293 Cells> 97%ActivehFc 51048-MNAH 5 Citations MouseGM-CSF/CSF2HEK293 Cells> 95 %ActiveNative ...
这是因为就机制而言,G-CSF可以促进造血干细胞的募集和中心粒细胞的生成。但是,G-CSF治疗受多种因素的限制,可能导致治疗效果欠佳。目前已知一种名为癌胚抗原相关黏附分子1的免疫球蛋白超家族成员,Carcinoembryonic Antigen Cellular Adhe...
产品名称:小鼠粒细胞巨噬细胞集落刺激因子(GM-CSF)ELISA试剂盒合作单位:高校//科研院;实验类型:夹心法/间接法/竞争法;反应时间: 1-5h所需样本体积: 50-100ul检测波长: 450 nm特:不与其它可溶性结构类似物交叉反应。重复性:板内变异系数小于10% ,板间变异系数小于15% 。应用范围:用于体外定量检测血清、血浆...
No cross-reactivity in ELISA with Human CSF1, Human GCSF, Human IL5Ra, Human IL3Ra, Human IL1a, Human IL1B-proform, Human IL2, Human IL3, Human IL4, Human IL6, Human TNFa, and Human TNFb. 靶标信息 The GM-CSF gene encodes for a cytokine that regulates the production, differentia...
These CSFs are critical to the proper maintenance of steady-state macrophage development, although with different roles. GM-CSF has a role in inducing emergency hematopoiesis not in steady state, and influences the pathogenesis of various inflammatory as well as autoimmune diseases (5). In this ...