Furthermore, glutamyl-prolyl tRNA synthetase is part of a multisynthetase complex which, under the influence of γ-interferon, translocates to the γ-interferon-activated inhibitor of translation complex (GAIT), where it causes gene-specific translational silencing of a proinflammatory protein (Sampath ...
(GlyRS), an essential enzyme in protein synthesis, also plays a critical role in neddylation. In human cells, knockdown of GlyRS, but not knockdown of a different tRNA synthetase, decreased the global level of neddylation and caused cell-cycle abnormality. This function of GlyRS is achieved ...
Neddylation is a post-translational modification that controls cell cycle and proliferation by conjugating the ubiquitin-like protein NEDD8 to specific targets. Here we report that glycyl-tRNA synthetase (GlyRS), an essential enzyme for protein synthesis
Their α2 homodimeric structures generally share a C-terminal anticodon binding domain with the exception of seryl-tRNA synthetase (SerRS). In contrast, the α2β2 tetrameric structures vary greatly within the IIC subclass, and GlyRS is one of the most divergent synthetases among all class II...
The present invention relates to a novel method of screening an agent for preventing or treating cancer using glycyl-tRNA synthetase (GRS) and cadherin (CDH). More particularly, it relates to a method of screening and test agent which modulates the binding level of GRS or their fragment with ...
Their α2 homodimeric structures generally share a C-terminal anticodon binding domain with the exception of seryl-tRNA synthetase (SerRS). In contrast, the α2β2 tetrameric structures vary greatly within the IIC subclass, and GlyRS is one of the most divergent synthetases among all class II...