The AKT signaling pathway plays critical roles in the resolution of inflammation. However, the underlying mechanisms of anti-inflammatory regulation and signal coordination remain unclear. Here, we report that anti-inflammatory AKT signaling is coordinated by glutamyl-prolyl-tRNA synthetase 1 (EPRS1). ...
Human EPRS1 is a 1512 amino acid-long bifunctional tRNA synthetase (Fig.1a) that resides exclusively in the MSC (Fig.1b). Due to its physical flexibility, which correlates with its multicellular functions, the overall structure of EPRS1 has not yet been determined. However, the structures of...
2004. Noncanonical function of glutamyl-prolyl-tRNA synthetase: Gene-specific silencing of translation. Cell 119: 195-208.Sampath P , Mazumder B , Seshadri V et al . ( 2004 ) Noncanonical function of glutamyl-prolyl-tRNA synthetase : gene-specific silencing of translation . Cell 119 : 195 –...
蛋白别名:Bifunctional aminoacyl-tRNA synthetase; Bifunctional glutamate/proline--tRNA ligase; Cell proliferation-inducing gene 32 protein; glutamate tRNA ligase; Glutamatyl-prolyl-tRNA synthetase; glutamine-proline-tRNA synthetase; glutaminyl-tRNA synthetase; proliferation-inducing gene 32 protein; ...
上海玉博生物科技有限公司 主要致力于“Rabbit polyclonal to Glutamyl Prolyl tRNA synthetase Abcam ab31531 ”的生产销售。多年的“Rabbit polyclonal to Glutamyl Prolyl tRNA synthetase Abcam ab31531 ”生产与销售的经验,与各行业新老用户建立了稳定的合作关系,
EPRS is the only fused tRNA synthetase, with two distinct aminoacylation activities, and a non-canonical translation regulatory function mediated by the WHEP domains in the linker. Investigating the duplications, deletions and divergence of WHEP domains, we traced the bifunctional EPRS to choanozo...
tRNA synthetases are essential to protein synthesis. Kim and colleagues identify a non-translational function for glutamyl-prolyl-tRNA synthetase during viral infection that promotes the anti-viral activity of the antiviral signaling protein MAVS. The ma
Translation of the EPRS mRNA encoding glutamyl-prolyl-tRNA synthetase is suggested to be enhanced in response to eIF2α-P (11). The 5′-leader of EPRS contains two UUG initiation codons and three in-frame CUG initiation codons that collectively encode three putative uORFs. Using heterologous ...
Human bifunctional glutamyl-prolyl tRNA synthetase (EPRS) contains three WHEP domains (R123) linking two catalytic domains. These three WHEP domains have been shown to be involved in protein–protein and protein–nucleic acid interactions. In translational control of gene expression, R12 repeats is ...
This effect was inhibited in prolyl-transfer RNA synthetase (PRS)-suppressed LX2 cells. Using the promoter luciferase assay, TGF-β1-mediated collagen I, α1 chain transcription and γ2 basal laminin transcription in LX2 cells were down-regulated by EPRS suppression, suggesting that EPRS may play...