The process, with its routing of electrons from the GAPDH-generated NADH to the mitochondrial GPO, the observed apparent particle-bound nature of glycolytic enzymes and formation of glycerol in an organism without detectable glycerol-3-phosphatase was explained by the finding that the major part of...
rapid desensitization of the receptors prevents the Na+influx from activating metabolism. Kainate causes a more important intracellular Na+change and a small but significant stimulation of aerobic glycolysis. This effect could be explained by the fact that kainate, in contrast to AMPA, leads to only...
In this review we describe evidence indicating that the alterations in glucose metabolism in hypertrophied hearts cannot be explained simply by changes in PDC expression or control. Additional mechanisms that may lead to an altered balance of pyruvate metabolism in cardiac hypertrophy are discussed, ...
The results show for the first time that the feasibility of glycolysis can be explained by thermodynamics only if (1) correct standard data are used and if (2) the conditions in the cell at non-equilibrium states are accounted for in the analyses. The results here will help to determine ...
It is analyzed whether the structural design of contemporary glycolysis can be explained theoretically on the basis of optimization principles originating from natural selection during evolution. Particular attention is paid to the problem of how the kinetic and thermodynamic properties of the glycolytic pa...
required for the health of long-range axons of glutamatergic neurons; (2) NMNAT2 is essential for fast axonal transport; (3) NMNAT2 ensures the proper NAD+/NADH redox potential for glycolysis on vesicular cargos; and (4) NAD supplementation rescues the axonal phenotypes caused by NMNAT2 loss...
This can in part be explained by failure to eradicate a subset of cells within the tumour that are then capable of sustaining tumour growth. These cells share a number of features with stem cells and have therefore been called cancer stem cells (CSCs). CSCs have been isolated from a ...
our study explained the action mechanism of mechanical stretching stimulating the MscL-G22S on the energy metabolism of SCs. We also demonstrated that inhibition of PI3K activation by its inhibitor, LY294002, significantly abolished the upregulation of glycolysis and OXPHOS by MscL-G22S activation in...
In this review we describe evidence indicating that the alterations in glucose metabolism in hypertrophied hearts cannot be explained simply by changes in PDC expression or control. Additional mechanisms that may lead to an altered balance of pyruvate metabolism in cardiac hypertrophy are discussed, ...
This result may be explained by considering the finding that a similar number of patients in group B whose tumors were ER/PR positive had received endocrine therapy (14/20 [70%], aromatase inhibitor or antiestrogen). At the time of FDG PET/CT, FDG accumulation in MBC may have been ...