EAN is characterized by the accumulation of activated T cells and macrophages in the peripheral nerve system. The rapid weight loss (Fig. 2), which cannot be completely explained by the disease-associated paralysis [29], suggests an abnormal metabolism in EAN. According to previous reports, after...
rapid desensitization of the receptors prevents the Na+influx from activating metabolism. Kainate causes a more important intracellular Na+change and a small but significant stimulation of aerobic glycolysis. This effect could be explained by the fact that kainate, in contrast to AMPA, leads to only...
In this review we describe evidence indicating that the alterations in glucose metabolism in hypertrophied hearts cannot be explained simply by changes in PDC expression or control. Additional mechanisms that may lead to an altered balance of pyruvate metabolism in cardiac hypertrophy are discussed, ...
In this review we describe evidence indicating that the alterations in glucose metabolism in hypertrophied hearts cannot be explained simply by changes in PDC expression or control. Additional mechanisms that may lead to an altered balance of pyruvate metabolism in cardiac hypertrophy are discussed, ...
required for the health of long-range axons of glutamatergic neurons; (2) NMNAT2 is essential for fast axonal transport; (3) NMNAT2 ensures the proper NAD+/NADH redox potential for glycolysis on vesicular cargos; and (4) NAD supplementation rescues the axonal phenotypes caused by NMNAT2 loss...
It is analyzed whether the structural design of contemporary glycolysis can be explained theoretically on the basis of optimization principles originating from natural selection during evolution. Particular attention is paid to the problem of how the kinetic and thermodynamic properties of the glycolytic pa...
This can in part be explained by failure to eradicate a subset of cells within the tumour that are then capable of sustaining tumour growth. These cells share a number of features with stem cells and have therefore been called cancer stem cells (CSCs). CSCs have been isolated from a ...
. We further developed a thermodynamic activity-based approach that allows to correctly determine the feasibility of glycolysis under different chosen conditions. The results show for the first time that the feasibility of glycolysis can be explained by thermodynamics only if (1) correct standard data...
One of the possible causes of metabolic alteration in cancer cells is a decreased substrate supply and this can sometimes be explained by increased pyruvate dehydrogenase kinase (PDK) activity. PDK is an inhibitor of pyruvate dehydrogenase (PD) which converts pyruvate produced during glycolysis into ...
OctandRAS onthecontrolofmitochondrialrespirationandglutamineutilizationhasbeenexplainedrecentlyonartificial modelsoftumorigenesis.Likewise,thegenerationofinducedpluripotentstemcellsfromoncogeneactivation alsoshowedtheroleofC-MYCandOctintheregulationofmitochondrialbiogenesisandROSgeneration.Inthis reviewarticleweputemphasison...