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The process, with its routing of electrons from the GAPDH-generated NADH to the mitochondrial GPO, the observed apparent particle-bound nature of glycolytic enzymes and formation of glycerol in an organism without detectable glycerol-3-phosphatase was explained by the finding that the major part of...
In this review we describe evidence indicating that the alterations in glucose metabolism in hypertrophied hearts cannot be explained simply by changes in PDC expression or control. Additional mechanisms that may lead to an altered balance of pyruvate metabolism in cardiac hypertrophy are discussed, ...
Approximately 50% of variation was explained by two principal components (PCs) in PC analysis, which corresponded approximately to “ribosomes and translation” (PC1, separated MP&DM from WT&TM) and “mRNA splicing and processing” (PC2, separated MP&WT from DM&TM) (Fig. S1A, File S3)....
The measured fluorescence of Cyto-pHluorin was called FMax and was background subtracted, as explained above. Cytosolic pH of the basal and Oligomycin treatments were determined using the following modified Hender- son-Hasselbalch equation: pH Basal = pKa − log[( 1+10pKa−7.4 FBasal )...
[20]. In this study, we revealed the prognostic value and biological functions of miR-598-3p and its targets RMP and IGF1r in gastric cancer, which explained why and how hypoxic gastric cancer cells acquire a metastatic tendency toward glucose metabolic reprogramming. These alterations triggered ...
EAN is characterized by the accumulation of activated T cells and macrophages in the peripheral nerve system. The rapid weight loss (Fig. 2), which cannot be completely explained by the disease-associated paralysis [29], suggests an abnormal metabolism in EAN. According to previous reports, after...
. We further developed a thermodynamic activity-based approach that allows to correctly determine the feasibility of glycolysis under different chosen conditions. The results show for the first time that the feasibility of glycolysis can be explained by thermodynamics only if (1) correct standard data...
One of the possible causes of metabolic alteration in cancer cells is a decreased substrate supply and this can sometimes be explained by increased pyruvate dehydrogenase kinase (PDK) activity. PDK is an inhibitor of pyruvate dehydrogenase (PD) which converts pyruvate produced during glycolysis into ...
rapid desensitization of the receptors prevents the Na+influx from activating metabolism.Kainatecauses a more important intracellular Na+change and a small but significant stimulation of aerobic glycolysis. This effect could be explained by the fact that kainate, in contrast to AMPA, leads to only a...