Key Concepts Animal glycolipids are amphipathic molecules composed of a lipid embedded in a cell membrane and a glycan extending outwards. Most animal glycolipids are glycosphingolipids (GSLs), glycans carried o
The structures and putative roles of glycosphingolipids in helminthic infections, which affect more than 25% of the world's population are discussed in Sect. 3. Plant glycolipids reviewed in Sect. 4 represent a structurally and functionally heterogeneous class of molecules, which gain augmenting ...
Glycolipids are complex glycoconjugates composed of a glycan headgroup and a lipid moiety. Their modular biosynthesis creates a vast amount of diverse and often isomeric structures, which fulfill highly specific biological functions. To date, no gold-sta
... In this regard, we propose that glycolipids can act as efficient energy molecules, because of their composition; that is, glycolipids are lipid molecules, with sugars attached to them. Where are glycolipids found in the body? Glycolipids are found on the surface of all eukaryotic cell ...
To determine whether the stimulatory capacity of SMC124 and EF77 required internalization into cells, and perhaps lysosomal processing, we tested the ability of these glycosphingolipids to load onto immobilized CD1d molecules. These molecules were then tested to determine if they stimulate iNKT cell...
Glycosphingolipid (GSL) expression in developing tissues is spatially and temporally regulated. Post-synthetic glycan modifications such as sulfation, phosphorylation, and O-acetylation are associated with specific cell types within complex tissues and with specific developmental stages. Sulfated GSLs (...
Extensive crystal structure analysis of CD1 molecules with bound ligands suggests that CD1 binding is less specific, which supports the observation that the length of a lipid tail does not greatly affect the immunomodulatory profile of a given glycolipid [6]. Instead, the highly specific interaction...
Gold nanoparticles have particular properties distinct from those of bulk gold crystals, and such nanoparticles are used in various applications in optics, catalysis, and drug delivery. Many reports on microbial synthesis of gold nanoparticles have appeared. However, the molecular details (reduction and...
They can be used, in further studies, for testing the carbohydrate specificity of the recognition process between liposomes coated with C6-functionalized sugars and MCF-7 cells. The target molecules 1 and 2 (Fig. 1) contain a cholesteryl residue, known for its ability to integrate into lipid ...
It has now been found, surprisingly, that, at acid pH, glycolipids are virtually completely retained by a membrane that has a cut-off size for molecules with a molecular weight of more than 30,000. The invention consequently relates to a process for preparing purified glycolipids which is char...