For example, Siglec-1 (CD169/Sialoadhesin; Sn) on macrophages/dendritic cells mediates the uptake of viruses and extracellular vesicles (EVs) through binding gangliosides in their membrane5,6,22,23,24. Siglec-4 (myelin-associated glycoprotein; MAG) on oligodendrocytes binds gangliosides on neurons...
The examples include the types of carbohydrates found in the dolichol pyrophosphates used in glycoprotein biosynthesis, with the full oligosaccharide shown in shape/color symbols. The bottom structure demonstrated that other glycans are also found in some organisms. The structure shown by glycan symbols...
Siglec-4 (mye- lin-associated glycoprotein; MAG) on oligodendrocytes binds ganglio- sides on neurons to regulate neurite growth25. Moreover, Siglec-7 on natural killer cells recognizes gangliosides on cancer cells or EVs from cancer cells to prevent immune cell activation24,26. The fact that ...
Fluctuation forces for the clustering of tightly membrane-associated proteins (or nanoparticles) will need to be measured directly using appropriate force sensors, and the structural intricacies underlying the capacity of GL-Lect drivers such as galectin-3 (Gal3) to switch from glycoprotein to glycoli...