The uptake of glucose is a rate-limiting step in carbohydrate metabolism. Reaction 1 Once inside the cells the glucose is converted into glucose 6-phosphate by hexokinase. Not only is glucose 6-phosphate more reactive than glucose itself but, once a sugar has been phosphorylated, it is unable...
Finally, we focused on Gys2 which is liver glycogen synthase and catalyzes the rate-limiting step in the synthesis of glycogen. Furthermore, loss-of-function mutations of Gys2 cause type 0 Glycogen Storage Disease (GSD) in children, who have glycogen storage defect and hypoglycemia as main ...