This has rarely been a clinical problem, except in patients with diabetes. Transient hepatomegaly due to glycogen storage may occur, but this is reversible after cessation of administration.10-11 Pharmacokinetics Limited pharmacokinetic data are available on glycerol. When given orally to humans, it...
High-performance thin-layer chromatogram (HPTLC) of cerebral cortex neutral lipids (A), acidic lipids (B), and gangliosides (C) in normal and Sandhoff disease mice (M), cats (C), and humans (H). The amount of neutral lipids and acidic lipids spotted per lane was equivalent to ...
N.V.Bhagavan,Chung-EunHa, inEssentials of Medical Biochemistry (Second Edition), 2015 Glycolysis Glycolysis is common to most organisms and in humans occurs in virtually all tissues. Ten reactions culminate in the formation of two pyruvate molecules from each glucose molecule. All 10 reactions occur...
among different kinds of alcohols9,20. Skin is the outermost organ of humans, which acts as the barrier between internal organs and the environment. Many skin diseases can be histopathologically diagnosed by observing morphological changes in different skin layers. However, the skin is a high ...
Additional complexity in promoter B regulation was reported wherein the promoter B is sensitive to thyroid hormone in rats54 but not in humans56, thus suggesting species-differential regulation. Although it is not exactly a transcriptional regulation, miR-1 and miR-206 have been shown to regulate...
Shark liver oil is a source of alkylglycerols which have been studied as anti-cancer agents in several clinical trials. Moreover, alkylglycerols have been investigated for the treatment of radiation induced side effects and for their ability to boost the immune system. Several experimental studies...
This review covers the most important studies of alkylglycerols in both animals and humans.IannittiTommasoPalmieriBeniaminoIannitti, T., Palmieri, B., 2010. An update on the therapeutic role of alkylglycerols. Mar. Drugs 8, 2267-2300.
HumansBronchitisCoughChronic DiseaseGlycerolExpectorantsMaximal Midexpiratory Flow RateDouble-Blind MethodAdultIn a double-blind trial, 29 patients were treated for stable, chronic bronchitis with iodinated glycerol (Organidin, 60 mg four times daily; n = 16) or placebo (n = 13). The study ...
In dogs and in cats, the saturation point for glycerol is significantly higher than in humans: 1.1–1.62 mmol/L [109,110]. However, a large amount of the glycerol that enters the kidney proximal tubule cells is used in the gluconeogenesis process, which contributes up to 20–25% of the ...
In humans, individuals homozygous or heterozygous for mutations that induce loss of function of ANGPTL3 develop combined hypolipidemia, characterized by a reduction in plasma levels of all classes of lipoproteins, such as VLDL, LDL, and HDL [85,86]. Functional studies revealed that the mutant ...